Results 61 to 70 of about 43,202 (221)

A Rabbit Model for the Evaluation of Drugs for Treating the Chronic Phase of Botulism

Toxins, 2021
Antitoxin, the only licensed drug therapy for botulism, neutralizes circulating botulinum neurotoxin (BoNT). However, antitoxin is no longer effective when a critical amount of BoNT has already entered its target nerve cells.
Amram Torgeman, Eran Diamant, Eyal Dor, Arieh Schwartz, Tzadok Baruchi, Alon Ben David, Ran Zichel   +6 more
doaj   +1 more source

Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics [PDF]

, 2018
The proteobacteria Variovorax sp. WDL1, Comamonas testosteroni WDL7, and Hyphomicrobium sulfonivorans WDL6 compose a triple-species consortium that synergistically degrades and grows on the phenylurea herbicide linuron.
Anders, Aziz, Beliaev, Bers, Bleichrodt, Boon, Breugelmans, Breugelmans, Cerqueda-Garcia, Colwell, Dealtry, Dejonghe, Dwyer, Foster, Frias-Lopez, Garbeva, Garcia, Gonzalez-Torres, Hansen, Horemans, Horemans, Horemans, Horemans, Horinouchi, Ilut, Kanehisa, Kell, Kimes, Krol, Love, MacLean, Maeyer, Nadell, Palama, Perez, Reasoner, Rickard, Rosenthal, Russell, Sabag-Daigle, Sambrook, Shimoyama, Subramoni, Suzuki, Tai, Teramoto, Ward, Wenter, West, Wu, Zerbino, Zgur-Bertok, Zhou   +52 more
core   +2 more sources

The 3D genome of Gigaspora margarita unveils stable chromatin and nucleolar organization and symbiont‐dependent genome dynamics

New Phytologist, EarlyView.
Summary Arbuscular mycorrhizal fungi (AMF) are widespread plant symbionts that enhance nutrient acquisition and influence ecosystem productivity. Previous chromosome‐level assemblies of the model species Rhizophagus irregularis revealed a two‐compartment genome architecture (active A and repressed B chromatin compartments), yet its conservation across ...
Ken Mugambi, Jordana Oliveira, Franco Magurno, Alessandra Salvioli di Fossalunga, Mara Novero, Luisa Lanfranco, Stefano Ghignone, Gökalp Yildirir, Yan Wang, Paola Bonfante, Nicolas Corradi   +10 more
wiley   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

Mono- and multidomain defense toxins of the RelE/ParE superfamily

mBio
Toxin–antitoxin (TA) modules are widely distributed across prokaryotes, often existing in large numbers despite their associated fitness costs. Most type II TA modules are bicistronic operons encoding a monodomain toxin and its cognate protein antitoxin.
Kenn Gerdes
doaj   +1 more source

Recurrent diphtheria outbreaks in Nigeria: A review of the underlying factors and remedies

Immunity, Inflammation and Disease, 2023
Introduction The introduction of the diphtheria−tetanus−pertussis (DTP) vaccine into childhood immunization programs resulted in its widespread elimination in high‐income countries. However, Nigeria is currently experiencing an outbreak.
Nasir Abdulrasheed, Lukman Lawal, Abdulazeez B. Mogaji, Ahmed O. Abdulkareem, Abdulrahman K. Shuaib, Sodiq G. Adeoti, Opeyemi P. Amosu, Abdulmujeeb O. Muhammad‐Olodo, Abdulwahab O. Lawal, Tawakalitu A. Jaji, Toufik Abdul‐Rahman   +10 more
doaj   +1 more source

Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]

, 2014
A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core   +2 more sources

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence [PDF]

, 2014
Nearly all bacteria exhibit a type of phenotypic growth described as persistence that is thought to underlie antibiotic tolerance and recalcitrant chronic infections.
Behiels, Ester, Devreese, Bart, Elegheert, Jonathan, Félix, Jan, Savvides, Savvas, Vergauwen, Bjorn, Wen, Yurong   +6 more
core   +2 more sources

Turmeric and curcumin: From traditional medicine to modern therapeutic applications

JSFA reports, Volume 6, Issue 5, Page 160-178, May 2026.
Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem, Khurram Afzal, Asad Abbas, Talha Bin Iqbal, Abdul Malik, Javaria Saeed, Mutjardah Zarrish, Bipindra Pandey   +7 more
wiley   +1 more source