Chaperone addiction of toxin–antitoxin systems
Nature Communications, 2016 Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al.
Patricia Bordes +8 more
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Structural insights into chaperone addiction of toxin-antitoxin systems [PDF]
Nature Communications, 2019 SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC).
Valérie Guillet +12 more
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A Case of Botulism Fast Adjusting with Antitoxin Administration in the Early Period and the Use of Electromyography in Diagnosis [PDF]
, 2021 Botulism is a rare but potentially life-threatening neuroparalytic syndrome caused by the action of a neurotoxin caused by the bacterium Clostridium botulinum. Early diagnosis and early treatment is important. In cases where botulism occurs sporadically,
Merve Feyza Yüksel +8 more
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Toxin–Antitoxin Systems in Pathogenic Bacteria [PDF]
, 2021 © 2021 by the authorToxin–antitoxin (TA) systems, which are ubiquitously present in plasmids, bacterial and archaeal genomes, are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition [1–5].
Alonso, Juan Carlos, Juan C. Alonso
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Toxins, 2020 Ricin, produced from the castor beans of Ricinus communis, is a cytotoxin that exerts its action by inactivating ribosomes and causing cell death. Accidental (e.g., ingestion of castor beans) and/or intentional (e.g., suicide) exposure to ricin through ...
Sarah J. Whitfield +6 more
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RNA antitoxin SprF1 binds ribosomes to attenuate translation and promote persister cell formation in Staphylococcus aureus [PDF]
, 2021 Persister cells are a subpopulation of transiently antibiotic-tolerant bacteria associated with chronic infection and antibiotic treatment failure. Toxin-antitoxin systems have been linked to persister cell formation but the molecular mechanisms leading ...
Brielle, Régine +5 more
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Post-Exposure Anti-Ricin Treatment Protects Swine against Lethal Systemic and Pulmonary Exposures
Toxins, 2020 Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor bean plant), is one of the most lethal toxins known. To date, there is no approved post-exposure therapy for ricin exposures.
Reut Falach +14 more
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IN VITRO ESTIMATION OF POTENCY OF SOME CLOSTRIDIAL TOXOIDS [PDF]
Assiut Veterinary Medical Journal, 2005 The efficacy of the toxin binding inhibition test (ToBi) as an in vitro testing of potency for multicomponent clostridial vaccine was compared with the currently used toxin neutralization test (TN).
M.M. FAYEZ, A.A. EL-MENISY, A.Z. HUSSEIN
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Modeling sRNA-Regulated Plasmid Maintenance. [PDF]
PLoS ONE, 2017 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid.
Chen Chris Gong, Stefan Klumpp
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Investigation of the Frequency of Foodborne Botulism in Patients Referred to Loghman Hospital in Tehran City, Iran, From 2008 to 2019 [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Foodborne botulism is a fatal paralytic illness caused mainly by the neurotoxin produced by an anaerobic bacterium called Clostridium botulinum. In this study, the frequency of foodborne botulism in patients referred to a hospital in Iran has
Mohammad Mehdi Soltan Dallal +7 more
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