Results 61 to 70 of about 46,189 (213)
The FEBS Journal, EarlyView.When overexpressed in Staphylococcus aureus, the type I toxins SprA1 and SprA2 form membrane pores, with SprA1 creating stable pores and SprA2 forming transient ones. Both induce concomitant membrane depolarization, ATP release, and growth arrest, while only SprA1 causes membrane permeabilization due to its stable pore formation.
Laurence Fermon +10 more
wiley +1 more source
Molecular Microbiology, EarlyView.Using bioinformatic tools, we identified a diverse defensome in Actinobacillus pleuropneumoniae, featuring various defense mechanisms. Genomes show co‐occurring systems like CRISPR, Abi, and restriction‐modification (RM) systems, underscoring the complexity and dynamic nature of their defensome cargo.
Giarlã Cunha da Silva +1 more
wiley +1 more source
Vesiculation as potential novel pathogenic mechanism in autoimmune hemolytic anemia
Transfusion, EarlyView.Abstract Background Autoimmune hemolytic anemia (AIHA) is typically mediated by immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies, and more rarely by immunoglobulin A (IgA). The mechanism of red blood cell (RBC) destruction in IgA‐mediated AIHA is not well understood.
Esther C. W. de Boer +14 more
wiley +1 more source
Evaluating the effect of equine tetanus antitoxin on mortality rates of dogs affected by tetanus
Veterinary EvidencePICO Question In dogs with tetanus, does administering the equine tetanus antitoxin compared to not administering the antitoxin reduce mortality rates? Clinical bottom line Category of research Treatment.
Berry Wong
doaj +1 more source
Geometric Properties of Isostables and Basins of Attraction of Monotone Systems [PDF]
, 2017 In this paper, we study geometric properties of basins of attraction of monotone systems. Our results are based on a combination of monotone systems theory and spectral operator theory.
Mauroy, Alexandre, Sootla, Aivar
core +3 more sources
B Cells as a Host of Persistent Salmonella Typhimurium
Immunology, Volume 175, Issue 3, Page 292-299, July 2025.B cells: a niche for persistent Salmonella enterica serovar Typhimurium (S. Tm). In vitro, within B cells and in the absence of antibiotics, a persistent population of S. Tm emerges, where the SehA/B gene is implicated. Additionally, a replicative population of S. Tm is also present. Upon antibiotic administration, approximately 90% of the S.
Alonso D. Cruz‐Cruz +4 more
wiley +1 more source
Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei [PDF]
, 2013 The aim of this study was to identify and characterise type II toxin-antitoxin (TA) systems in Burkholderia pseudomallei, the causative agent of the human disease melioidosis. 8 putative TA systems were identified within the genome of B. pseudomallei
Butt, Aaron Trevor
core
AcrDB update: Predicted 3D structures of anti‐CRISPRs in human gut viromes
Protein Science, Volume 34, Issue 6, June 2025.Abstract Anti‐CRISPR (Acr) proteins play a key role in phage‐host interactions and hold great promise for advancing genome‐editing technologies. However, finding new Acrs has been challenging due to their low sequence similarity. Recent advances in protein structure prediction have opened new pathways for Acr discovery by using 3D structure similarity.
Minal Khatri +4 more
wiley +1 more source
The vapB-vapC operon of Acidovorax citrulli functions as a bona-fide toxin-antitoxin module
Frontiers in Microbiology, 2016 Toxin–antitoxin systems are commonly found on plasmids and chromosomes of bacteria and archaea. These systems appear as biscystronic genes encoding a stable toxin and a labile antitoxin, which protects the cells from the toxin’s activity. Under specific,
Reut eShavit +4 more
doaj +1 more source
Frontiers in Genetics, 2020 Survival of mycobacteria, both free-living and host-dependent pathogenic species, is dependent on their ability to evade being killed by the stresses they routinely encounter.
Valdir Cristovao Barth +2 more
doaj +1 more source