Results 61 to 70 of about 48,883 (257)

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

Toxins, 2020
Botulinum neurotoxin (BoNT) serotype E is one of three serotypes that cause the preponderance of human botulism cases and is a Tier 1 Select Agent. BoNT/E is unusual among BoNT serotypes for its rapid onset and short duration of intoxication.
Jacqueline M. Tremblay, Edwin Vazquez-Cintron, Kwok-Ho Lam, Jean Mukherjee, Daniela Bedenice, Celinia A. Ondeck, Matthieu T. Conroy, Skylar M. L. Bodt, Brittany M. Winner, Robert P. Webb, Konstantin Ichtchenko, Rongsheng Jin, Patrick M. McNutt, Charles B. Shoemaker   +13 more
doaj   +1 more source

Equine botulism

Equine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik, Robert Whitlock, Amy Johnson   +2 more
wiley   +1 more source

Generation of Highly Efficient Equine-Derived Antibodies for Post-Exposure Treatment of Ricin Intoxications by Vaccination with Monomerized Ricin

Toxins, 2018
Ricin, a highly lethal toxin derived from the seeds of Ricinus communis (castor beans) is considered a potential biological threat agent due to its high availability, ease of production, and to the lack of any approved medical countermeasure against ...
Reut Falach, Anita Sapoznikov, Ron Alcalay, Moshe Aftalion, Sharon Ehrlich, Arik Makovitzki, Avi Agami, Avishai Mimran, Amir Rosner, Tamar Sabo, Chanoch Kronman, Yoav Gal   +11 more
doaj   +1 more source

What traits are carried on mobile genetic elements, and why? [PDF]

, 2010
Although similar to any other organism, prokaryotes can transfer genes vertically from mother cell to daughter cell, they can also exchange certain genes horizontally.
A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Mochizuki, A Norman, A Philppon, A Wagner, AD O’Brien, AS Griffin, B Sanchez, BJ Crespi, BK Kozlowicz, BMM Ahmer, BR Levin, C Buchrieser, CE White, CF Amabile-Cuevas, CG Kurland, CM Thomas, CM Yates, CT Bergstrom, D Gevers, D J Rankin, DJ Rankin, DM Livermore, E Cascales, E Cascales, E Lerat, E P C Rocha, E Polzleitner, ES Egan, F Bushman, F de la Cruz, F Delsuc, F Dionisio, F Dionisio, F Harrison, F Rousset, FM Stewart, FR Slater, G Gil, G Hardin, GA Dykes, H Knothe, H Ochman, I Chen, I Kobayashi, I Rasched, J Hacker, J Lederberg, J Paulsson, J Smith, J Zupan, JB Ferdy, JB Xavier, JC Diaz Ricci, JE Bouma, JL Martinez, JL Martínez, JL Sachs, JL Sachs, JR van der Ploeg, K Lee, KM Oliver, KR Foster, KR Foster, KR Foster, L Buts, L Chao, L Keller, L Lehmann, L Lehmann, L Riboli-Sasco, L Van Melderen, LE Orgel, LJ Johnson, LN Lili, LS Frost, M Achtman, M Ackermann, M Touchon, MA Riley, MI Bahl, MI Bahl, MK Waldor, MP Nuti, N Goldenfeld, ND Zinder, PB Rainey, PE Turner, PE Turner, R Barrangou, R Korona, RD Magnuson, RE Fox, RJ Ellis, RJF Haft, RM Anderson, RM Anderson, RM May, S Alizon, S P Brown, SA West, SA West, SA West, SA West, SC Slater, SJ Sorensen, SM Faruque, SP Brown, SP Brown, SP Brown, SP Brown, SR Bordenstein, T Nogueira, TF Cooper, TF Cooper, VL Arcus, WD Hamilton, WD Hamilton, WG Eberhard   +123 more
core   +3 more sources

The genome and stage‐specific transcriptomes of the carrot weevil, Listronotus oregonensis, reveal adaptive mechanisms for host specialisation and symbiotic interactions

Insect Molecular Biology, EarlyView.
Comprehensive genome and stage‐specific transcriptomes reveal 14,637 genes in Listronotus oregonensis, advancing genetic insights into a key agricultural pest. Compared with related species, L. oregonensis exhibits reduced chemoreceptor gene families but expanded detoxification gene clusters, reflecting its narrow host range and adaptability.
Dave T. Ste‐Croix, Annie‐Ève Gagnon, Benjamin Mimee   +2 more
wiley   +1 more source

Mono- and multidomain defense toxins of the RelE/ParE superfamily

mBio
Toxin–antitoxin (TA) modules are widely distributed across prokaryotes, often existing in large numbers despite their associated fitness costs. Most type II TA modules are bicistronic operons encoding a monodomain toxin and its cognate protein antitoxin.
Kenn Gerdes
doaj   +1 more source

Shaping Pulses to Control Bistable Biological Systems [PDF]

, 2015
In this paper we study how to shape temporal pulses to switch a bistable system between its stable steady states. Our motivation for pulse-based control comes from applications in synthetic biology, where it is generally difficult to implement real-time ...
Angeli, David, Oyarzun, Diego, Sootla, Aivar, Stan, Guy-Bart   +3 more
core   +2 more sources

Causes and consequences of bacterial local adaptation via MGEs in the plant microbiome

New Phytologist, EarlyView.
Summary Adaptations that enable plant‐associated bacteria to fill disparate niches comprise a critical component of microbial diversity. Genes that confer locally adaptive bacterial traits, ranging from heavy metal resistance to pathogen or symbiont infectivity, often reside within mobile genetic elements (MGEs) that can move between genomes.
Stephanie Porter, Dominique Holtappels, Angeliqua Montoya, Britt Koskella   +3 more
wiley   +1 more source

Escherichia coli EHEC Germany outbreak preliminary functional annotation using BG7 system [PDF]

, 2011
We have annotated the European outbreak E. coli EHEC genome sequenced by BGI (6-2-2011) and assembled with MIRA by Nick Loman (6-2-2011 ). Our system BG7, Bacterial Genome annotation of Era7 Bioinformatics, predicts ORFs and annotates them based on ...
Eduardo Pareja, Eduardo Pareja-Tobes, Marina Manrique, Pablo Pareja-Tobes, Raquel Tobes   +4 more
core   +2 more sources

Defense Systems and Prophage Detection in Streptococcus mutans Strains

Molecular Oral Microbiology, EarlyView.
ABSTRACT Although the species is extensively studied, limited data are available on antiphage defense systems (APDSs) in Streptococcus mutans. The present study aimed to explore the diversity and the occurrence of APDSs and to search for prophages in the genomes of clinical isolates of S. mutans using bioinformatics tools.
Olivier Claisse, Cas Mosterd, Claire Le Marrec, Johan Samot   +3 more
wiley   +1 more source