Results 91 to 100 of about 491,510 (368)
ANTITUMOR ACTIVITY OF ECHINOSPORIN
The Journal of Antibiotics, 1985 Echinosporin isolated from a Streptomyces culture showed antitumor activity against rodent tumor models such as leukemia P388, P388/VCR, and fibrosarcoma Meth 1. It was marginally active against melanoma B16 and sarcoma 180. It was not active against Lewis lung carcinoma and xenograft MX-1. It inhibited the colony formation of HeLa S3 cells with a wide
M, Morimoto, R, Imai
openaire +3 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Combination chemotherapy with anticancer agents and OK-432 [PDF]
, 1974 Antitumor effects of the combination chemotherapy with hemolytic streptococcus preparation, OK-432, and various anticancer agents were observed on experimental tumors and human cancers.
Sugiyama, Motoharu +6 more
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Molecules, 2010 New approaches for the synthesis of hydrazide-hydrazone derivatives were demonstrated as well as some heterocyclizations of such derivatives to afford 1,3,4-triazine, pyridine and 1,3,4-oxadiazine derivatives.
Rafat M. Mohareb, Abeer A. Mohamed
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Enhanced antitumor activity of surface-modified iron oxide nanoparticles and an α-tocopherol derivative in a rat model of mammary gland carcinosarcoma [PDF]
, 2017 Daniel Horák,1 Vitaliy Igorovych Pustovyy,2 Andrii Valeriyovich Babinskyi,2 Olga Mikhailovna Palyvoda,2 Vasyl Fedorovich Chekhun,3 Igor Nikolaevich Todor,3 Oleksandr Ivanovich Kuzmenko2 1Department of Polymer Particles, Institute of ...
Horák D +6 more
core
Extraction, Chemical Composition, and Anticancer Potential of Origanum onites L. Essential Oil
Molecules, 2019 Origanum species are plants rich in volatile oils that are mainly used for culinary purposes. In recent years, there has been a growing interest in the biological activities of their essential oils. Origanum onites L.
Katerina Spyridopoulou +8 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Synthesis and Antiangiogenic Activity of Novel Gambogic Acid Derivatives
Molecules, 2012 Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity.
Li-Juan Chen +11 more
doaj +1 more source