Results 71 to 80 of about 491,510 (368)

Glycyrrhetinic Acid Maintains Intestinal Homeostasis via HuR

Frontiers in Pharmacology, 2019
Glycyrrhetinic acid (GA) is one of the main components of the traditional Chinese medicine of licorice, which can coordinate and promote the effects of other medicines in the traditional prescription.
Gang Chen, Bei Bei, Yuan Feng, Xuezheng Li, Zhe Jiang, Jian-Yong Si, De-Gang Qing, Juan Zhang, Juan Zhang, Ning Li   +9 more
doaj   +1 more source

Lactylation and antitumor immunity

Frontiers in Immunology
Lactylation, a recently discovered post-translational modification (PTM), plays a critical role in cancer biology. Warburg effect induces lactate accumulation, which serves as a metabolic end-product and intercellular signaling mediator within the tumor microenvironment (TME).
Yang, Biao, Li, Lingyu, Shi, Dongmei, Zhong, Tao, Xiong, Huabao   +4 more
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Therapeutic antitumor efficacy of tumor-derived autophagosome (DRibble) vaccine on head and neck cancer [PDF]

, 2015
Hang Su,1,* Qiong Luo,2,* Hao Xie,3 Xiaofeng Huang,1 Yanhong Ni,1 Yongbin Mou,1 Qingang Hu1,4 1Center Laboratory of Stomatology, Stomatological Hospital Affiliated Medical School, 2State Key Laboratory of Pharmaceutical Biotechnology, School of Life ...
Huang XF, Mou YB, Luo Q, Xie H, Hu QG, Su H, Ni YH   +6 more
core  

Betulinic Acid-Nitrogen Heterocyclic Derivatives: Design, Synthesis, and Antitumor Evaluation in Vitro

Molecules, 2020
Betulinic acid (BA) is a star member of the pentacyclic triterpenoid family, which exhibits great prospects for antitumor drug development. In an attempt to develop novel antitumor candidates, 21 BA-nitrogen heterocyclic derivatives were synthetized, in ...
Yuqin Yang, Tianxin Xie, Xuehao Tian, Nana Han, Xiaojing Liu, Hongshan Chen, Jinchai Qi, Feng Gao, Wen Li, Qianwen Wu, Su Huo, Yuhao Gu, Ziqi Dai, Penglong Wang, Haimin Lei   +14 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Assessment of antitumor activity and acute peripheral neuropathy of 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) [PDF]

, 2014
Takayoshi Ueno,1 Kazuhira Endo,1 Kiyomi Hori,2 Noriyuki Ozaki,2 Akira Tsuji,1 Satoru Kondo,1 Naohiro Wakisaka,1 Shigeyuki Murono,1 Kazunori Kataoka,3,4 Yasuki Kato,5 Tomokazu Yoshizaki11Division of Otolaryngology-Head and Neck Surgery, 2Department of ...
Kondo S, Murono S, Kato Y, Endo K, Ozaki N, Hori K, Kataoka K, Ueno T, Tsuji A, Wakisaka N, Yoshizaki T   +10 more
core  

Sphingosine‐1‐Phosphate Receptor 3 Confers Tumor Metastasis in Lung Cancer Resistant to Third‐Generation EGFR Inhibitor

MedComm
The third‐generation EGFR tyrosine kinase inhibitor (TKI) osimertinib (AZD9291) has significantly improved the survival in EGFR‐mutant lung cancer patients.
Mengzhen Lai, Jiaying Chen, Ye Qin, Hui Zhang, Zilu Pan, Tao Zhang, Linjiang Tong, Haotian Tang, Gang Bai, Qiupei Liu, Yan Li, Fang Feng, Peiran Song, Yingqiang Liu, Yi Chen, Yan Fang, Bencan Tang, Meiyu Geng, Ker Yu, Hao Chen, Jian Ding, Hua Xie   +21 more
doaj   +1 more source

Dehydrocostuslactone inhibits proliferation and promotes apoptosis of human hepatocellular carcinoma cell line HepG2 [PDF]

Jichu yixue yu linchuang, 2020
Objective To investigate the effects of dehydrocostuslactone treatment on the proliferation and apoptosis of human HepG2 cells and potential mechanisms.
MIAO Jia-wei, CHEN Jie, DENG Xue-song, XIONG Shu, LI Guo-li, MA Qiang
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source