Results 81 to 90 of about 447,103 (266)

Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation

Signal Transduction and Targeted Therapy
Third-generation EGFR tyrosine kinase inhibitors (TKIs), exemplified by osimertinib, have demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer (NSCLC).
Tao Zhang, Zilu Pan, Jing Gao, Qingqing Wu, Gang Bai, Yan Li, Linjiang Tong, Fang Feng, Mengzhen Lai, Yingqiang Liu, Peiran Song, Yi Ning, Haotian Tang, Wen Luo, Yi Chen, Yan Fang, Hui Zhang, Qiupei Liu, Yudi Zhang, Hua Wang, Zhiwei Chen, Yi Chen, Meiyu Geng, Hongbin Ji, Guilong Zhao, Hu Zhou, Jian Ding, Hua Xie   +27 more
doaj   +1 more source

Network biology to artificial intelligence: building the next generation of predictive drug discovery

Frontiers in Immunology
Drug discovery remains constrained by high attrition rates, prolonged timelines, and limited ability to translate molecular insights into effective therapies.
Kumar Selvarajoo
doaj   +1 more source

Synthesis and Antiangiogenic Activity of Novel Gambogic Acid Derivatives

Molecules, 2012
Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity.
Li-Juan Chen, Ai-Hua Peng, Jing-Xiang Qiu, Fei Peng, Guang-Cheng Wang, Jin-Ying Chen, Neng Qiu, Liang Ma, Shi-Chao He, Qin-Yuan Xu, Rong-Hong Zhang, Tao Chen   +11 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A natural PKM2 targeting agent as a potential drug for breast cancer treatment

Clinical and Translational Medicine, 2023
Xin‐Yue Shang, Yu‐Jue Wang, Zi‐Lin Hou, Xin‐Ye Wang, Hao Zhang, Chen‐Yu Yang, Ji‐Chong Li, Xiao‐Xiao Huang, Shao‐Jiang Song, Guo‐Dong Yao   +9 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Artificial Antigen Presenting Cells With Preclustered anti-CD28/-CD3/-LFA-1 Monoclonal Antibodies Are Highly Effective To Induce The Ex-Vivo Expansion Of Functional Human Antitumor T Cells [PDF]

, 2007
Effective adoptive T cell therapy requires the _ex vivo_ generation of functional T lymphocytes with a long lifespan _in vivo_. We evaluated _in vitro_ T cell expansion by artificial antigen presenting cells (aAPC) generated with activating (human anti ...
Roberta Zappasodi, Carmelo Carlo-Stella, Lorena Passoni, Salvatore Albani, Claudia Vegetti, Massimo Di Nicola, Alessandro M. Gianni, Roberta Mortarini, Alessandra Molla, Andrea Anichini   +9 more
core  

Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Molecular Cancer, 2023
Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie   +20 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway

, 2017
Meng Su,1 Baoli Qin,1 Fang Liu,2 Yuze Chen,2 Rui Zhang2 1Department of Internal Medicine, 2Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Liaoning, China Abstract: Colorectal ...
Su M, Chen Y, Zhang R, Qin B, Liu F
core