Results 181 to 190 of about 840,802 (388)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting autophagy potentiates antitumor activity of Met-TKIs against Met-amplified gastric cancer

, 2019
Xiaoting Lin, Zhi Peng, Xiaojuan Wang, Jianling Zou, Dongshao Chen, Zuhua Chen, Zhongwu Li, Bin Dong, Jing Gao, Lin Shen   +9 more
openalex   +1 more source

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells [PDF]

, 2011
Dharminder Chauhan, Ze Tian, Bin Zhou, Deborah J. Kuhn, Robert Z. Orlowski, Noopur Raje, Paul Richardson, Kenneth C. Anderson   +7 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells

, 2012
Tetsuya Tamatani, Tarannum Ferdous, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa, Youji Miyamoto   +10 more
openalex   +2 more sources

Antitumor Peptides from Marine Organisms [PDF]

, 2011
Lanhong Zheng, Yuejun Wang, Jun Sheng, Jinpeng Wang, Zheng Yuan, Xiukun Lin, Mi Sun   +6 more
openalex   +1 more source

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

Science, 2002
M. Dudley, J. Wunderlich, P. Robbins, J. Yang, P. Hwu, D. Schwartzentruber, S. Topalian, R. Sherry, N. Restifo, Amy M. Hubicki, M. Robinson, M. Raffeld, P. Duray, C. Seipp, Linda J. Rogers-Freezer, K. Morton, S. Mavroukakis, D. White, S. Rosenberg   +18 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Evaluation of antitumor and anti-angiogenic activity of bioactive compounds from Cinnamomum tamala : In vitro , in vivo and in silico approach

, 2015
Deepavali R. Thanekar, Jayesh B. Dhodi, Nitin B. Gawali, Archana Raju, Padmini S. Deshpande, Mariam S. Degani, Archana R. Juvekar   +6 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source