Results 231 to 240 of about 531,165 (296)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Acriflavine-empowered IR780-PTX albumin nanoparticles for reinforced synergistic photochemotherapy. [PDF]

Adv Biotechnol (Singap)
Li D, Wang T, Liu H, Yao Y, Lu T, Wang R, Jiang X, Zhang X, Sun M, Peng Y, Yang Y, Shao N, Ding D, Zhi F.   +13 more
europepmc   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Single-cell dissection of hepatocellular carcinoma immunity: from heterogeneous subtypes to precision therapeutics. [PDF]

Front Immunol
Liang Y, Wu H, Qiu Y, Mo Q, Chen P, Li M, Lin H.   +6 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Recurrent Glioblastoma and the Tumor Immune Landscape: Emerging Immunotherapeutic Strategies. [PDF]

Immunotargets Ther
Cao Z, Tong S, Wang Z, Ji C, Zhang C, Dai X, Wu B.   +6 more
europepmc   +1 more source

Tumor-Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation. [PDF]

MedComm (2020)
Bao W, Qu X, Wang Y, Huang D, Zhang H, Dong M, Sun H, Yang Z, Li X.   +8 more
europepmc   +1 more source

Targeting PIM2 improves antitumor immunity through promoting effector function and persistence of CD8 T cells. [PDF]

J Clin Invest
Wu Y, Tian L, Pugel A, Alimohammadi R, Cheng Q, Cui W, Nishimura MI, Ball LE, Lin CW, Mehrotra S, Kraft AS, Yu XZ.   +11 more
europepmc   +1 more source

Synergistic Gene Immunotherapy for Lung Cancer via Targeted Nanomedicine Restoring Genetic Tumor Suppression and Activating STING Pathway. [PDF]

ACS Nano
Chen W, Zheng X, Wu Y, Xu Y, Ni H, Xiao P, Cai W, Wang K.   +7 more
europepmc   +1 more source

B cells and humoral immunity in melanoma: regulatory and autoimmune-like features and implications for immunotherapy. [PDF]

Oncoimmunology
Booth L, Mahmood M, Chen X, Jacków-Malinowska J, Tsoka S, Tull TJ, Karagiannis SN.   +6 more
europepmc   +1 more source