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Ribonucleases and their antitumor activity
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2001The antitumor effect of ribonucleases was studied with animal ribonucleolytic enzymes, bovine pancreatic RNase A, bovine seminal RNase (BS-RNase), onconase and angiogenin. While bovine pancreatic RNase A exerts a minor antitumor effect, BS-RNase and onconase exert significant effects.
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Antitumor Metabolites of Fungi
Current Bioactive Compounds, 2015The exploitation of the antitumor properties of fungal secondary metabolites is one of the fundamental objectives pursued by a multiplicity of research groups and laboratories working on the characterization of natural products worldwide. The availability of a synthetic framework on such a vast interdisciplinary topic can enhance the current knowledge ...
Nicoletti R, FIORENTINO, Antonio
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The antitumor potential of bisphosphonates
Seminars in Oncology, 2002Bisphosphonates are primarily known for their ability to inhibit osteoclast-mediated bone resorption and to slow the release of calcium and other bone minerals into the blood stream. However, recent preclinical research has shown that bisphosphonates also exhibit potent antitumor activity.
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Initiating an antitumor attack
Science, 2017Cancer Cancer is notorious for relapsing after treatment. Such relapses are driven by tumor-initiating cells, a type of stem cell that gives rise to tumors. Damelin et al. determined that a protein called PTK7 is frequently present on tumor-initiating cells and developed an antibody-drug conjugate targeting it.
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2015
ART acts on tumor cells differentially by the threshold concentrations. High-dose ART kills tumor cells upon the inhibition of NOS, whereas low-dose ART benefits tumor propagation due to induce cytoprotective NO production. Pro-oxidants that antagonize antioxidants can potentiate ART’s antitumor capacity. The combination of ART with pro-oxidants should
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ART acts on tumor cells differentially by the threshold concentrations. High-dose ART kills tumor cells upon the inhibition of NOS, whereas low-dose ART benefits tumor propagation due to induce cytoprotective NO production. Pro-oxidants that antagonize antioxidants can potentiate ART’s antitumor capacity. The combination of ART with pro-oxidants should
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Antitumor Agents Based on Metal–Organic Frameworks
Angewandte Chemie - International Edition, 2021Peng Gao, Yuanyuan Chen, Wei Pan
exaly
Antitumor antibodies for therapy
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1989Karl Erik Hellström+1 more
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Gastroenteropancreatic Neuroendocrine Tumors
Ca-A Cancer Journal for Clinicians, 2018Mauro Cives, Jonathan Strosberg
exaly