Results 251 to 260 of about 531,165 (296)

The Roles of CD8+ T Cell Subsets in Antitumor Immunity.

Trends in Cell Biology, 2020
Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that produce interferon-(IFN) γ. However, recent findings have challenged this notion because multiple subsets of CD8+ T cells have been described, each with distinct
M. St. Paul, P. Ohashi
semanticscholar   +1 more source

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

Science, 2020
Targeting STING for cancer therapy Activation of the STING (stimulator of interferon genes) protein by cyclic dinucleotide metabolites plays a critical role in antitumor immunity.
E. Chin, Chenguang Yu, Vincent F. Vartabedian, Ying Jia, M. Kumar, A. M. Gamo, W. Vernier, Sabrina H. Ali, Mildred Kissai, Daniel C. Lazar, N. Nguyen, Laura E. Pereira, B. Benish, A. Woods, S. Joseph, A. Chu, Kristen A. Johnson, Philipp N. Sander, Francisco Martínez-Peña, Eric N. Hampton, T. Young, D. Wolan, A. Chatterjee, P. Schultz, H. Petrassi, J. Teijaro, L. Lairson   +26 more
semanticscholar   +1 more source

New antitumoral cyclopeptides

Amino Acids, 1994
Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines.
E, Bernardi, J L, Fauchère, G, Atassi, P, Viallefont, R, Lazaro   +4 more
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Antitumor septacidin analogs

Journal of Medicinal Chemistry, 1977
In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice.
E M, Acton, K J, Ryan, A E, Luetzow
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Radiolabeled antitumor agents

Seminars in Nuclear Medicine, 1976
Bleomycin serves as a useful prototype for a study of the various properties required in a radiopharmaceutical for tumor imaging. Both in vitro and in vivo results using bleomycin labeled with a large number of different radionuclides have now been reported.
D A, Goodwin, C F, Meares
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Potential antitumor phenoxazines

Medicinal Research Reviews, 1991
From the various studies cited, spanning more than forty years, it is clear that some members of the phenoxazine and benzophenoxazine dye family selectively stain certain tumors and, when given in suitable concentrations in the feed, can prolong life and shrink tumors.
N, Motohashi, L A, Mitscher, R, Meyer
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Noncytotoxic, Antitumor Polysaccharides

1976
Publisher Summary This chapter provides an overview of the available information on host-mediated, antitumor action of noncytotoxic polysaccharides extracted from different botanical sources. Serratia marcescens polysaccharide has been reported to be active against a number of tumors, such as Sarcoma 180, Ehrlich carcinoma, Guerin carcinoma ...
Roy L. Whistler, Alfred A. Bushway, Prem P. Singh, Waro Nakahara, Reiko Tokuzen   +4 more
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Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity

Journal of Drug Targeting, 1996
To enhance the selective delivery of antitumor drugs into regional lymph nodes and cancerous tissues via a hyaluronate (HA) receptor (CD44), we synthesized HA-mitomycin C complex and HA-epirubicin complex. To investigate the specific distribution of HA into regional lymph nodes and to evaluate the HA receptor on lewis lung carcinoma cells, we also ...
K, Akima, H, Ito, Y, Iwata, K, Matsuo, N, Watari, M, Yanagi, H, Hagi, K, Oshima, A, Yagita, Y, Atomi, I, Tatekawa   +10 more
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Preexisting antitumor immunity augments the antitumor effects of chemotherapy

Cancer Immunology, Immunotherapy, 2013
Efficacy of cancer chemotherapy is generally believed to be the result of direct drug killing of tumor cells. However, increased tumor cell killing does not always lead to improved efficacy. Herein, we demonstrate that the status of antitumor immunity at the time of chemotherapy treatment is a critical factor affecting the therapeutic outcome in that ...
Lingbing, Zhang, Dongdong, Feng, Lynda X, Yu, Kangla, Tsung, Jeffrey A, Norton   +4 more
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Antitumor Effects of Interferon

Acta Oncologica, 1973
Both natural and recombinant interferons have shown definite antitumor activity in some patients with some malignancies. The history of the development of interferon as an antitumor agent is reviewed, with special attention to its use in mice bearing 'spontaneously' appearing tumors and in mice injected with tumorigenic viruses or transplantable tumor ...
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