Results 341 to 350 of about 840,802 (388)
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Anti-Cancer Agents in Medicinal Chemistry, 2007
Natural and synthetic carbazoles, either in a pure substituted or in an annellated substituted form, represent an important and heterogeneous class of anticancer agents, which has grown considerably over the last two decades. Many carbazole derivatives have been tested for cyctotoxic activity, some of them have entered clinical trials, but only ...
Asche, Christian, Demeunynck, Martine
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Natural and synthetic carbazoles, either in a pure substituted or in an annellated substituted form, represent an important and heterogeneous class of anticancer agents, which has grown considerably over the last two decades. Many carbazole derivatives have been tested for cyctotoxic activity, some of them have entered clinical trials, but only ...
Asche, Christian, Demeunynck, Martine
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Mini-Reviews in Medicinal Chemistry, 2004
Most anticancer titanium compounds act against tumors in the gastrointestinal tract. Activity towards breast, lung and skin (melanoma) cancers is shown by some as well. Among their appealing properties is that they do not show common side effects of widely used cytostatic agents such as emesis, alopecia or bone marrow impairment.
Caruso Francesco, Rossi Miriam
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Most anticancer titanium compounds act against tumors in the gastrointestinal tract. Activity towards breast, lung and skin (melanoma) cancers is shown by some as well. Among their appealing properties is that they do not show common side effects of widely used cytostatic agents such as emesis, alopecia or bone marrow impairment.
Caruso Francesco, Rossi Miriam
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Amino Acids, 1994
Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines.
E, Bernardi +4 more
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Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines.
E, Bernardi +4 more
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Journal of Medicinal Chemistry, 1977
In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice.
E M, Acton, K J, Ryan, A E, Luetzow
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In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice.
E M, Acton, K J, Ryan, A E, Luetzow
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Seminars in Nuclear Medicine, 1976
Bleomycin serves as a useful prototype for a study of the various properties required in a radiopharmaceutical for tumor imaging. Both in vitro and in vivo results using bleomycin labeled with a large number of different radionuclides have now been reported.
D A, Goodwin, C F, Meares
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Bleomycin serves as a useful prototype for a study of the various properties required in a radiopharmaceutical for tumor imaging. Both in vitro and in vivo results using bleomycin labeled with a large number of different radionuclides have now been reported.
D A, Goodwin, C F, Meares
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Potential antitumor phenoxazines
Medicinal Research Reviews, 1991From the various studies cited, spanning more than forty years, it is clear that some members of the phenoxazine and benzophenoxazine dye family selectively stain certain tumors and, when given in suitable concentrations in the feed, can prolong life and shrink tumors.
N, Motohashi, L A, Mitscher, R, Meyer
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Noncytotoxic, Antitumor Polysaccharides
1976Publisher Summary This chapter provides an overview of the available information on host-mediated, antitumor action of noncytotoxic polysaccharides extracted from different botanical sources. Serratia marcescens polysaccharide has been reported to be active against a number of tumors, such as Sarcoma 180, Ehrlich carcinoma, Guerin carcinoma ...
Roy L. Whistler +4 more
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Journal of Drug Targeting, 1996
To enhance the selective delivery of antitumor drugs into regional lymph nodes and cancerous tissues via a hyaluronate (HA) receptor (CD44), we synthesized HA-mitomycin C complex and HA-epirubicin complex. To investigate the specific distribution of HA into regional lymph nodes and to evaluate the HA receptor on lewis lung carcinoma cells, we also ...
K, Akima +10 more
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To enhance the selective delivery of antitumor drugs into regional lymph nodes and cancerous tissues via a hyaluronate (HA) receptor (CD44), we synthesized HA-mitomycin C complex and HA-epirubicin complex. To investigate the specific distribution of HA into regional lymph nodes and to evaluate the HA receptor on lewis lung carcinoma cells, we also ...
K, Akima +10 more
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Preexisting antitumor immunity augments the antitumor effects of chemotherapy
Cancer Immunology, Immunotherapy, 2013Efficacy of cancer chemotherapy is generally believed to be the result of direct drug killing of tumor cells. However, increased tumor cell killing does not always lead to improved efficacy. Herein, we demonstrate that the status of antitumor immunity at the time of chemotherapy treatment is a critical factor affecting the therapeutic outcome in that ...
Lingbing, Zhang +4 more
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Science Translational Medicine, 2021
Description Local immunotherapy with an mRNA mixture encoding four cytokines mobilizes a systemic antitumor response and promotes tumor eradication. Encoding antitumor immunity Cytokine-based treatments for cancer have been hindered by both off-target ...
C. Hotz +36 more
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Description Local immunotherapy with an mRNA mixture encoding four cytokines mobilizes a systemic antitumor response and promotes tumor eradication. Encoding antitumor immunity Cytokine-based treatments for cancer have been hindered by both off-target ...
C. Hotz +36 more
semanticscholar +1 more source