Results 331 to 340 of about 491,510 (368)
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Cardiotoxicity of Antitumor Drugs
Chemical Research in Toxicology, 2008Many antitumor drugs cause "on treatment" cardiotoxicity or introduce a measurable risk of delayed cardiovascular events. Doxorubicin and other anthracyclines cause congestive heart failure that develops in a dose-dependent manner and reflects the formation of toxic drug metabolites in the heart.
Pierantonio, Menna +2 more
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Obesity and antitumor immunity
Science Signaling, 2022Obesity reversibly suppresses the antitumor activity of CD8 + T cells in mice and humans.
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Amino Acids, 1994
Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines.
E, Bernardi +4 more
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Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines.
E, Bernardi +4 more
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Noncytotoxic, Antitumor Polysaccharides
1976Publisher Summary This chapter provides an overview of the available information on host-mediated, antitumor action of noncytotoxic polysaccharides extracted from different botanical sources. Serratia marcescens polysaccharide has been reported to be active against a number of tumors, such as Sarcoma 180, Ehrlich carcinoma, Guerin carcinoma ...
Roy L. Whistler +4 more
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Potential antitumor phenoxazines
Medicinal Research Reviews, 1991From the various studies cited, spanning more than forty years, it is clear that some members of the phenoxazine and benzophenoxazine dye family selectively stain certain tumors and, when given in suitable concentrations in the feed, can prolong life and shrink tumors.
N, Motohashi, L A, Mitscher, R, Meyer
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Initiating an antitumor attack
Science, 2017Cancer Cancer is notorious for relapsing after treatment. Such relapses are driven by tumor-initiating cells, a type of stem cell that gives rise to tumors. Damelin et al. determined that a protein called PTK7 is frequently present on tumor-initiating cells and developed an antibody-drug conjugate targeting it.
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Antitumor effect of avermectins
European Journal of Pharmacology, 2004The effect of a mixture of naturally occurring aversectin C and avermectin B(1) on the growth of ascites and solid experimental tumors of mice was studied. It was shown for the first time that avermectins possess a pronounced antitumor action. When added at nontoxic doses, they significantly suppressed the growth of ascites Ehrlich carcinoma and P388 ...
Victor A, Drinyaev +9 more
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Molecular and Cellular Biochemistry, 1981
Tuftsin, a physiological tetrapeptide derived from the Fc region of leukophilic IgG possesses a variety of immunopotentiating properties including the ability to act as an immunotherapeutic agent against the experimental tumors, L1210 leukemia and Cloudman S-91 melanoma. Although the mechanism of action of tuftsin in vivo is not known, several types of
K, Nishioka +3 more
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Tuftsin, a physiological tetrapeptide derived from the Fc region of leukophilic IgG possesses a variety of immunopotentiating properties including the ability to act as an immunotherapeutic agent against the experimental tumors, L1210 leukemia and Cloudman S-91 melanoma. Although the mechanism of action of tuftsin in vivo is not known, several types of
K, Nishioka +3 more
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Actinomycin and Antitumor Antibiotics
American Journal of Clinical Pathology, 1969Actinomycin D forms a stable complex with DNA and thereby inhibits theDNA-dependentsynthesisof RNA. The biochemical effectsof this antibiotic upon cells in culture are interpretable in terms of the complex described above. They include inhibition of the synthesis of ribosomal RNA at low drug concentrations, of all RNA species at moderate concentrations
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Antioxidants as Antitumor Promoters
1986Phorbol 12-myristate 13-acetate (PMA) is a potent mouse skin tumor promoter which has been researched most intensively over the years in an attempt to understand the biochemical mechanisms involved in tumor promotion, PMA stimulates a multitude of cellular and biochemical reactions (82), Three of these, induction of ornithine decarboxylase (ODC ...
W J, Kozumbo, P A, Cerutti
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