Results 321 to 330 of about 491,510 (368)
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Journal of Drug Targeting, 1996
To enhance the selective delivery of antitumor drugs into regional lymph nodes and cancerous tissues via a hyaluronate (HA) receptor (CD44), we synthesized HA-mitomycin C complex and HA-epirubicin complex. To investigate the specific distribution of HA into regional lymph nodes and to evaluate the HA receptor on lewis lung carcinoma cells, we also ...
K, Akima +10 more
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To enhance the selective delivery of antitumor drugs into regional lymph nodes and cancerous tissues via a hyaluronate (HA) receptor (CD44), we synthesized HA-mitomycin C complex and HA-epirubicin complex. To investigate the specific distribution of HA into regional lymph nodes and to evaluate the HA receptor on lewis lung carcinoma cells, we also ...
K, Akima +10 more
openaire +2 more sources
Preexisting antitumor immunity augments the antitumor effects of chemotherapy
Cancer Immunology, Immunotherapy, 2013Efficacy of cancer chemotherapy is generally believed to be the result of direct drug killing of tumor cells. However, increased tumor cell killing does not always lead to improved efficacy. Herein, we demonstrate that the status of antitumor immunity at the time of chemotherapy treatment is a critical factor affecting the therapeutic outcome in that ...
Lingbing, Zhang +4 more
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Synthesis and antitumor activity of analogs of the antitumor antibiotic chartreusin
Journal of Medicinal Chemistry, 1980First isolated in 1953 from a fermentation broth, chartreusin (1) has received renewed interest as a result of substantial antitumor activities recently demonstrated in several murine test systems. Poor water solubility frustrated formulation attempts, and rapid biliary excretion observed in mice made 1 an improbable candidate for clinical development ...
M, Takai, Y, Uehara, J A, Beisler
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Antitumor and Antitumor-Promoting Actions of Macrophages and Their Relationship with Estrogen
Oncology, 2009Silica provides, in fact, a remarkable example of selective toxicity for macrophage by a substance of simple chemical composition and low chemical reactivity. Intraperitoneal injection of silica resulted in an increase of growth rate of subcutaneously implanted mouse sarcoma 180 (S1 80) in female BALB/c mice and of tumor incidence of two-stage mouse ...
L, Yu, R, Ma, T, Yu
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Bufadienolides and their antitumor activity
Natural Product Reports, 2011Since 1998, a great number of bufadienolides have been reported from plants, animals and plant cell suspensions, as well as from fungi and bacteria cultures. This review summarizes both new bufadienolides and those obtained from new sources, together with data regarding the antitumor activity of bufadienolide derivatives.
Gao, Huimin +3 more
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Antitumor Effects of Interferon
Acta Oncologica, 1973Both natural and recombinant interferons have shown definite antitumor activity in some patients with some malignancies. The history of the development of interferon as an antitumor agent is reviewed, with special attention to its use in mice bearing 'spontaneously' appearing tumors and in mice injected with tumorigenic viruses or transplantable tumor ...
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Seminars in Nuclear Medicine, 1976
Bleomycin serves as a useful prototype for a study of the various properties required in a radiopharmaceutical for tumor imaging. Both in vitro and in vivo results using bleomycin labeled with a large number of different radionuclides have now been reported.
D A, Goodwin, C F, Meares
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Bleomycin serves as a useful prototype for a study of the various properties required in a radiopharmaceutical for tumor imaging. Both in vitro and in vivo results using bleomycin labeled with a large number of different radionuclides have now been reported.
D A, Goodwin, C F, Meares
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The antitumor effects of interferon
Medical Oncology and Tumor Pharmacotherapy, 1974Interferons show antitumor activity in patients with various malignancies. The mechanism(s) of the antitumor effects are not altogether clear. In one experimental animal model discussed herein, mice were injected with Friend erythroleukemia cells and treated with mouse interferon alpha/beta.
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Antitumor Metabolites of Fungi
Current Bioactive Compounds, 2015The exploitation of the antitumor properties of fungal secondary metabolites is one of the fundamental objectives pursued by a multiplicity of research groups and laboratories working on the characterization of natural products worldwide. The availability of a synthetic framework on such a vast interdisciplinary topic can enhance the current knowledge ...
Nicoletti R, FIORENTINO, Antonio
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Journal of Medicinal Chemistry, 1977
In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice.
E M, Acton, K J, Ryan, A E, Luetzow
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In the first approach by total synthesis to the structure of the antitumor antibiotic septacidin, analogues have been obtained which show similar inhibition of RNA-DNA synthesis in cultured leukemia L1210 cells and similar activity against transplanted leukemia P388 in mice.
E M, Acton, K J, Ryan, A E, Luetzow
openaire +2 more sources