Results 301 to 310 of about 491,510 (368)

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

The relationship between gut microbiota and cancer immune response and immunotherapy. [PDF]

Front Immunol
Jia Y, Liu Y, Liu J.
europepmc   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

An MRI-visible nanotheranostic establishes a self-amplifying pyroptosis-STING-IFN-β circuit for CD8⁺ T cell immunoactivation. [PDF]

Mater Today Bio
Jing P, Wang L, Qiu X, Chen L, Xie D, Yu Y, Li B, Yan S, Wang G, Zhong Z, Fu W.   +10 more
europepmc   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants. [PDF]

Cancer Biol Ther
Illindala R, Yang Y, Mandt T, Webster N, Steinmetz N, Newton I.   +5 more
europepmc   +1 more source

Nucleotide signaling in neutrophils: a key player in cancer dynamics. [PDF]

Purinergic Signal
da Silva JLG, Sévigny J, Leal DBR.
europepmc   +1 more source

Valorization of the peel and husk of guaraná ( Paullinia cupana ): oil extraction, chemical composition, cytotoxicity, and antitumor potential

Leiliane do Socorro Sodré de Souza, Guilherme Teixeira de Azevedo, Eduardo Leonarski, Giovana Lima de Souza, Rafael Lopes e Oliveira, Sergio Duvoisin, Karina Cesca, Débora de Oliveira, Anderson Mathias Pereira, Ariane Mendonça Kluczkovski   +9 more
openalex   +1 more source

Macrophages in lung cancer: principal factors, regulatory mechanisms, and therapeutic opportunities: a narrative review. [PDF]

Transl Lung Cancer Res
Tian Y, Wu Y, Mi S, Zhang Y, Hu P, Qiao L, Deng G, Liang N, Zhang Y, Zhang J.   +9 more
europepmc   +1 more source

Leveraging the bacteria for enhanced cancer immunotherapy: from a perspective of synthetic biology. [PDF]

Cancer Biol Ther
Liu X, Zhang H, Du R, Liu Z, Ren Y, Yang X.   +5 more
europepmc   +1 more source