Results 291 to 300 of about 491,510 (368)

Antitumor Activity of Cannabinoids and Their Interaction with Chemotherapy: A Systematic Review and Meta-Analysis of Preclinical Evidence. [PDF]

Pharmaceuticals (Basel)
Creangă-Murariu I, Rezuș II, Karami R, Makolli A, Chifu C, Rancz A, Sipos Z, Ferdinandy P, Papp R, Teutsch B, Tamba BI, Hegyi P, Bunduc S.   +12 more
europepmc   +1 more source

MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells（MEK阻害薬と抗EGFR抗体薬はソトラシブの大腸がん細胞に対する耐性シグナルを克服し抗腫瘍効果を増強させる）

奈緒 本藤
openalex   +2 more sources

Versatile DNA‐Functionalized Biohybrid Hydrogel Platforms for Electrothermally Activated On‐Demand Payload Release

Advanced Science, EarlyView.
A DNA‐functionalized biohybrid hydrogel is developed by integrating Cu‐mediated nucleic acid microflowers into a thermoresponsive matrix, enabling electrothermally triggered, on‐demand payload release. The platform offers spatiotemporally controllable therapeutic delivery with promising applications in precision oncology, neural regulation, and chronic
Mengqiu Sun, Zhenshuai Tang, Jia Zhang, Rui Song, Wei Luo, Juan Huang, Jincheng Zeng, Zhen He, Hao Zhang   +8 more
wiley   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

cGAMP suppresses FTO expression to promote m⁶A modification and potentiate antitumor immunity. [PDF]

Cell Mol Life Sci
Feng P, Chen X, Guo D, Feng Z, Fu Y, Lai J, Yang X.   +6 more
europepmc   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Metabolic reprogramming as a driver of immune escape in melanoma: implications for immunotherapy. [PDF]

Front Immunol
Liang H, Han L, Feng X, Zhang L.
europepmc   +1 more source

Amplification of Endoplasmic Reticulum Stress via Inhibiting Lipid Droplet Formation to Enhance Chemodynamic Immunotherapy

Advanced Science, EarlyView.
An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai, Shaoru Zhuang, Yang Zhu, Rujiang Ao, Meili Yu, Tingting Cui, Jun Wang, Xuegang Niu, Hongwei Huang, Shanshan Peng, Yu He, Lisen Lin, Huanghao Yang   +12 more
wiley   +1 more source

Amino Acids as Targets for Immunotherapy against Solid Tumors. [PDF]

Cell Biochem Biophys
da Costa KVV, Passos GA, Botelho RJS, Ruza MSV, Dias-Lopes G, Silva RCMC.   +5 more
europepmc   +1 more source

Evaluation of nitensidine A antitumor activity, isolated from Pterogyne nitens, in an animal model of 4NQO-induced carcinogenesis

, 2016
Juliana Maria [UNESP] Sorbo
openalex   +1 more source