Results 11 to 20 of about 3,456 (163)

Physiological mechanisms and therapeutic targets in chronic cough. [PDF]

Physiol Rep
Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
Brown JC, Rhatigan KL, Price OJ, Cho PSP.   +3 more
europepmc   +2 more sources

The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID‐19‐ related cough: A randomized, controlled clinical trial

The Clinical Respiratory Journal, 2022
Introduction Cough is one of the most common presenting symptoms of COVID‐19, which can persist for weeks or months. Objective The goal of this study was to evaluate the effectiveness of gabapentin (GBT) alone and in combination with montelukast (MTL ...
Rasool Soltani, Sara Nasirharandi, Farzin Khorvash, Maryam Nasirian, Kian Dolatshahi, Atousa Hakamifard   +5 more
doaj   +1 more source

A phase 3, randomized, double-blind, clinical study to evaluate the long-term safety and efficacy of gefapixant in Japanese adult participants with refractory or unexplained chronic cough

Allergology International, 2022
Background: In two phase 3, global clinical trials (COUGH-1 and COUGH-2), the P2X3-receptor antagonist gefapixant significantly reduced objective 24-h cough frequency in participants with refractory or unexplained chronic cough (RCC or UCC) at a dosage ...
Akio Niimi, Hironori Sagara, Masashi Kikuchi, Ichiro Arano, Asako Sato, Masayoshi Shirakawa, Carmen La Rosa, David Muccino   +7 more
doaj   +1 more source

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End-of-Life Palliative Care. [PDF]

J Evid Based Med
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Li D, Yang Y, Zhang Y, Yue J, Dong B, Ge M, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University.   +7 more
europepmc   +2 more sources

Coughing in Small Animal Patients

Frontiers in Veterinary Science, 2020
Cough is one of the most common complaints in human medicine. In veterinary medicine cough is equally frequent and plays a significant role in an owner's perception of their pet's quality of life.
Brisa M. Hsieh, Alicia K. Beets
doaj   +1 more source

Deciphering the Antitussive, Expectorant, and Anti-Inflammatory Potentials of ShashamKyeongok-Go and Their Phytochemical Attributes: In Vivo Appraisal in ICR Mice

Applied Sciences, 2021
In this paper, we hypothesized that ShashamKyeongok-go (SKOG) is a mixed preparation of Adenophorae Radix powder (AR) and Kyeongok-go (KOG). SKOG may be served as a novel preventive and/or therapeutic agent for various respiratory diseases.
Jin-Ryul Hu, Chul-Jong Jung, Seong-Min Ku, Dae-Hwa Jung, Sae-Kwang Ku, Md. Mohibbullah, Hae-Jeung Lee, Jae-Suk Choi   +7 more
doaj   +1 more source

Saffron (Crocus sativus) petal as a new pharmacological target: a review [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Saffron petal is the main by-product of saffron processing which produced at high level but it is not applied and thrown out. Saffron petal is containing of several compounds such as mineral agents, anthocyanins, flavonoids, glycosides, alkaloids and ...
Azar Hosseini, Bibi Marjan Razavi, Hossein Hosseinzadeh   +2 more
doaj   +1 more source

Antipsychotic Drugs Efficacy in Dextromethorphan-Induced Psychosis

Biomedicines, 2023
Psychosis is known as a broad term of symptoms that cause serious disorganization of behavior, thinking, and perception of reality. One of the medicines that recently gained much attention in terms of its psychotic potential is dextromethorphan (DXM ...
Malgorzata Zaremba, Pawel Serafin, Patrycja Kleczkowska   +2 more
doaj   +1 more source

Implementation of a top five list to identify medical overuse in general practice according to patients’ viewpoint in 2019 in France

BMC Family Practice, 2021
Background There is a current trend to reassess the adequacy of care. Establishing top five lists by involving patients is one way to address medical overuse.
Agnès Hazard, Marion Debin, Corentin Hervé, Caroline Guerrisi, Camille Bonnet, Mathilde François   +5 more
doaj   +1 more source

Malva parviflora Leaves and Fruits Mucilage as Natural Sources of Anti-Inflammatory, Antitussive and Gastro-Protective Agents: A Comparative Study Using Rat Models and Gas Chromatography

Pharmaceuticals, 2022
Malva parviflora L., Little mallow, has been traditionally used as an alternative food source. It acts as a medicinal herb containing a potential source of mucilage thus herein; we aimed to assess the toxicity, anti-inflammatory, antitussive and gastro ...
Ahmed E. Altyar, Ans Munir, Saiqa Ishtiaq, Muhammad Rizwan, Khizar Abbas, Osama Kensara, Sameh S. Elhady, Waleed Y. Rizg, Fadia S. Youssef, Mohamed L. Ashour   +9 more
doaj   +1 more source