Results 101 to 110 of about 18,419 (261)

Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Quantitative systems pharmacology (QSP) models offer a useful platform to integrate drug pharmacology with knowledge about biological mechanisms across multiple scales and data sources into a unified quantitative framework. This makes them invaluable to address many relevant questions in drug research and development.
Johannes Tillil, Wilhelm Huisinga, Jane Knöchel   +2 more
wiley   +1 more source

Bothrops lanceolatus Envenoming in Martinique: A Historical Perspective of the Clinical Effectiveness of Bothrofav Antivenom Treatment

Toxins
Bothrofav, a monospecific antivenom, was introduced in June 1991 and has shown excellent effectiveness against life-threatening and thrombotic complications of Bothrops lanceolatus envenoming. Because of the reoccurrence of cerebral stroke events despite
Dabor Resiere, Jonathan Florentin, Hossein Mehdaoui, Hatem Kallel, Veronique Legris-Allusson, Papa Gueye, Remi Neviere   +6 more
doaj   +1 more source

A randomised controlled trial of two infusion rates to decrease reactions to antivenom.

PLoS ONE, 2012
BackgroundSnake envenoming is a major clinical problem in Sri Lanka, with an estimated 40,000 bites annually. Antivenom is only available from India and there is a high rate of systemic hypersensitivity reactions.
Geoffrey K Isbister, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Ariaranee Ariaratnam   +5 more
doaj   +1 more source

Reviewing evidence of the clinical effectiveness of commercially available antivenoms in sub-Saharan Africa identifies the need for a multi-centre, multi-antivenom clinical trial

PLoS Neglected Tropical Diseases, 2019
Background Snakebite envenoming kills more than more than 20,000 people in Sub-Saharan Africa every year. Poorly regulated markets have been inundated with low-price, low-quality antivenoms.
J. Potet, James Smith, L. McIver
semanticscholar   +1 more source

TOXIC SYNERGY: The Precarious Grasp of Human‐Snake Entanglements in a Thai Venom Facility

Cultural Anthropology, Volume 41, Issue 1, Page 30-56, February 2026.
ABSTRACT Venomous snakes offer unique insight into core topics of anthropological inquiry because they are both the cause of a disease, snakebite envenoming, and the source of the cure. At a Thai facility dedicated to venomous snake husbandry for the production of antivenom, the biological pharmaceutical used in the treatment of this disease, a team of
ERIN MCCONKEY
wiley   +1 more source

Local Ecological Knowledge and Cultural Perceptions of Snakes in Sudan

Ecology and Evolution, Volume 16, Issue 1, January 2026.
In Sudan, snakes are viewed through a mix of ecological, cultural, and spiritual lenses, shaping both conservation attitudes and health responses. Our survey (n = 192) across 16 states revealed frequent encounters, polarized conservation views, widespread killing of snakes, reliance on traditional remedies, and strong public support (95%) for ...
Rania M. H. Baleela, Muhammad E. M. O. Elamin, Abubakr Mohammad, Sara A. K. Saeed   +3 more
wiley   +1 more source

Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial.

PLoS Medicine, 2011
BackgroundEnvenoming from snakebites is most effectively treated by antivenom. However, the antivenom available in South Asian countries commonly causes acute allergic reactions, anaphylactic reactions being particularly serious.
H Asita de Silva, Arunasalam Pathmeswaran, Channa D Ranasinha, Shaluka Jayamanne, Senarath B Samarakoon, Ariyasena Hittharage, Ranjith Kalupahana, G Asoka Ratnatilaka, Wimalasiri Uluwatthage, Jeffrey K Aronson, Jane M Armitage, David G Lalloo, H Janaka de Silva   +12 more
doaj   +1 more source

Polymeric Nanoparticles for the Diagnosis and Treatment of Snakebite

Macromolecular Chemistry and Physics, Volume 227, Issue 1, 15 January 2026.
Snakebite envenomation affects between 1.8 and 5.5 million people annually, many of whom suffer disabilities or even death. Current antivenoms are composed of plasma‐derived antibodies. However, there remains an underexplored opportunity to utilise polymer‐based nanoparticles.
Neil Prabhakar, Thomas Oliver, Alexander N. Baker   +2 more
wiley   +1 more source

First Detection and Phylogenetic Analysis of Equine Hepacivirus (EqHV) in Iran

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
This study presents the first detection of Hepacivirus equi (EqHV) in the equine population of Khuzestan Province, Iran. Molecular analysis revealed a prevalence rate of 4.66%, while phylogenetic analysis confirmed that the strain IR1‐Ahvaz‐2024 belongs to EqHV subtype 1.
Mahdi Pourmahdi Borujeni, Hamzeh Ghobadian Diali, Alireza Ghadrdan Mashhadi, Mahdi Jalali Aliabad   +3 more
wiley   +1 more source

Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms

Brazilian Journal of Medical and Biological Research, 1997
Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atrox from Antioquia and Chocó (Colombia). The following antivenoms were
R. Otero, V. Núñez, J.M. Gutiérrez, A. Robles, R. Estrada, R.G. Osorio, G. Del-Valle, R. Valderrama, C.A. Giraldo   +8 more
doaj   +1 more source