Results 141 to 150 of about 928,338 (389)

The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer

Molecules
The aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral absorption.
Sheng Chang, Qiang Yang, Jiahuan Liu, Li Yin, Jihong Han, Lanlan Zong, Xiaohui Pu   +6 more
doaj   +1 more source

Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates

Molecules, 2019
Enterovirus 71 (EV-A71) is the main causative pathogen of childhood hand, foot and mouth disease. Effective medicine is currently unavailable for the treatment of this viral disease.
Yixuan Wang, Huiqiang Wang, Xinbei Jiang, Zhi Jiang, Tingting Guo, Xingyue Ji, Yanping Li, Yuhuan Li, Zhuorong Li   +8 more
doaj   +1 more source

Inactivation of murine norovirus on a range of copper alloy surfaces is accompanied by loss of capsid integrity

, 2015
Norovirus is one of the most common causes of acute viral gastroenteritis. The virus is spread via the fecal-oral route, most commonly from infected food and water, but several outbreaks have originated from contamination of surfaces with infectious ...
Keevil, C William, Summersgill, Emma N., Warnes, Sarah L.   +2 more
core   +1 more source

Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus [PDF]

, 2017
Lambda interferon (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s)
Baldridge, Megan T, Brown, Judy J, Dermody, Terence S, Lee, Sanghyun, McAllister, Nicole, Nice, Timothy J, Urbanek, Kelly, Virgin, Herbert W   +7 more
core   +2 more sources

Durable Electro‐Photothermal Superhydrophobic Coatings Based on Liquid‐Like Functionalization of Nanoparticles: Improved Water Repellency and Droplet Rebound

Advanced Materials Interfaces, EarlyView.
Multi‐walled carbon nanotubes (CNTs) are functionalized with liquid‐like linear polydimethylsiloxane (LPDMS) brushes and conventional solid‐like alkyl brushes, then incorporated into a resin and spray‐coated onto substrates. The resulting surfaces exhibit distinct water‐repellent behaviors.
Amirhossein Jalali Kandeloos, Tanja Eder, Youven Benseghir, Michael R. Reithofer, Manuel Luitz, Jia Min Chin   +5 more
wiley   +1 more source

The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells [PDF]

, 2008
The NS3 protein of the tenuivirus rice hoja blanca virus (RHBV) has previously been shown to represent the viral RNA interference (RNAi) suppressor and is active in both plant and insect cells by binding short interfering RNAs (siRNAs) in vitro.
Goldbach, R.W., Hemmes, J.C., Prins, M.W., Schnettler, E.   +3 more
core   +2 more sources

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

In Vivo Efficacy of a Broad-Spectrum Antiviral Combination Against Yellow Fever in a Hamster Model

Pathogens
Yellow fever virus (YFV) recurrently causes severe outbreaks in tropical regions of South America and Africa and an average of 30 to 40 thousand deaths worldwide each year. An effective vaccine is available but the coverage of the population in countries
Abbie E. Weight, Hunter Stanger, Robert J. Geraghty, Laurent F. Bonnac, Justin G. Julander   +4 more
doaj   +1 more source

Drop-out rate from the liver transplant waiting list due to HCC progression in HCV-infected patients treated with direct acting antivirals. [PDF]

, 2017
BACKGROUND & AIM: concerns about an increased hepatocellular carcinoma (HCC) recurrence rate following directly acting antiviral (DAA) therapy in cirrhotic patients with a prior complete oncological response have been raised. Data regarding the impact of
Angeli, Paolo, Burra, Patrizia, Cillo, Umberto, Farinati, Fabio, Ferrarese, Alberto, Forton, Dm, Franceschet, E, Gambato, M, Germani, Giacomo, Mescoli, Claudia, Romano, Antonietta, Rugge, Massimo, Russo, FRANCESCO PAOLO, Senzolo, Marco, Shalaby, S, Vitale, A, Zanetto, Alberto   +16 more
core   +1 more source

Light Mediated Sulfonylation/C–H Activation/Annulation of Benzimidazoles Derivatives Catalyzed by Diarylmethylium Tetrafluoroborate Salts: An Experimental and Computational Study

Advanced Synthesis &Catalysis, EarlyView.
Through the exploiting of visible‐light, a key photoactive complex, and an acid‐catalyzed proton‐coupled electron transfer, polycyclic sulfonylated benzimidazoles are obtained through a domino process including sulfonylation, C–H activation, and annulation. Diarylmethylium tetrafluoroborates are employed as inexpensive organocatalyst capable of forming
Polyssena Renzi, Davide Cerrina, Emanuele Azzi, Giovanni Ghigo, Annamaria Deagostino   +4 more
wiley   +1 more source