Results 121 to 130 of about 355,010 (330)

IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

Advanced Science, EarlyView.
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv, Wenzheng Zou, Lin Li, Shukui Zhang, Jiaqi Liang, Jiali Pu, Jianwei Jiao   +6 more
wiley   +1 more source

Synthesis and antiviral activity of some novel indole-2-carboxylate derivatives

Acta Pharmaceutica Sinica B, 2014
A series of novel indole-2-carboxylate derivatives were synthesized and assayed to determine their in vitro broad-spectrum antiviral activities. The biological results showed that some of the synthesized compounds exhibited potent broad-spectrum ...
Situ Xue, Linlin Ma, Rongmei Gao, Yuhuan Li, Zhuorong Li   +4 more
doaj   +1 more source

Antiviral Activity of Dicarbonyls and Related Compounds in Embryonated Eggs [PDF]

, 1957
William F. McLimans, G. E. Underwood, E. A. Slater, Emily Davis, R. A. Siem   +4 more
openalex   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

FIB‐3 index as a novel age‐independent predictor of liver fibrosis and prognosis in hepatocellular carcinoma patients undergoing hepatectomy

Annals of Gastroenterological Surgery, EarlyView.
Fibrosis‐3 index (FIB‐3) can stratify the risk of the survival and the recurrence‐free survival. The FIB‐3 index is a reliable, age‐independent tool for assessing liver fibrosis and prognosis in HCC patients post‐hepatectomy. Its use may improve clinical outcomes and support personalized treatment strategies. Abstract Background Liver fibrosis is a key
Yuki Imaoka, Masahiro Ohira, Tsuyoshi Kobayashi, Naruhiko Honmyo, Michinori Hamaoka, Takashi Onoe, Daisuke Takei, Koichi Oishi, Tomoyuki Abe, Toshihiro Nakayama, Miho Akabane, Kazunari Sasaki, Hideki Ohdan, Hiroshima Surgical study group of Clinical Oncology (HiSCO)   +13 more
wiley   +1 more source

Antiviral Effect Assay of Twenty Five Species of Various Medicinal Plants Families in Iran

Journal of Medicinal Plants, 2007
Background: Medicinal plants have been traditionally used for different kinds of ailments including infectious diseases. There is an increasing need for substances with antiviral activity since the treatment of viral infections with the available ...
SA Ziai, R Hamkar, HR Monavari, Z Norooz-Babaei, L Adibi   +4 more
doaj  

Mode of Action of the Antiviral Activity of Amantadine in Tissue Culture [PDF]

, 1965
C. E. Hoffmann, E Neumayer, R. F. Haff, Richard A. Goldsby   +3 more
openalex   +1 more source

Computational biology approach to uncover hepatitis C virus helicase operation [PDF]

arXiv, 2013
Hepatitis C virus helicase is a molecular motor that splits nucleic acid duplex structures during viral replication, therefore representing a promising target for antiviral treatment. Hence, a detailed understanding of the mechanism by which it operates would facilitate the development of efficient drug-assisted therapies aiming to inhibit helicase ...
arxiv  

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Experimental Medications Made with Сetraria islandica Showing Antiviral Activity against Influenza A Virus

Антибиотики и Химиотерапия
Background. To date, virologists have identified more than 25,000 influenza virus А serotypes, and their number will increase in the future. Therefore, the development of new antiviral drugs will always be relevant.The aim of the study is to obtain and ...
E. V. Makarevich, M. A. Protsenko, O. Yu. Mazurkov, E. I. Filippova, N. A. Mazurkova   +4 more
doaj   +1 more source