Results 131 to 140 of about 293,855 (303)

Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus

Communications Medicine
Background Effective antiviral therapy is lacking for most viral infections, and when available, is frequently compromised by the selection of resistance.
Baolong Pan, Simon J. Mountford, Maki Kiso, Danielle E. Anderson, Georgina Papadakis, Kate E. Jarman, Danielle R. Tilmanis, Belinda Maher, Thomas Tran, Jake Shortt, Seiya Yamayoshi, Yoshihiro Kawaoka, Philip E. Thompson, Sam A. Greenall, Nadia Warner   +14 more
doaj   +1 more source

Drug repurposing screens identify Tubercidin as a potent antiviral agent against porcine nidovirus infections

Virus Research
The emergence of new coronaviruses poses a significant threat to animal husbandry and human health. Porcine epidemic diarrhea virus (PEDV) is considered a re-emerging porcine enteric coronavirus, which causes fatal watery diarrhea in piglets.
Tianliang Wang, Guanmin Zheng, Zilu Chen, Yue Wang, Chenxu Zhao, Yaqin Li, Yixin Yuan, Hong Duan, Hongsen Zhu, Xia Yang, Wentao Li, Wenjuan Du, Yongtao Li, Dongliang Li   +13 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

The Influence of the AgNPs Ligand on the Antiviral Activity Against HSV-2 [PDF]

Emilia Tomaszewska,1 Katarzyna Bednarczyk,1 Martyna Janicka,2,3 Marcin Chodkowski,2 Malgorzata Krzyzowska,2 Grzegorz Celichowski,1 Jarosław Grobelny,1 Katarzyna Ranoszek-Soliwoda1 1University of Lodz, Faculty of Chemistry, Department of Materials ...
Tomaszewska E, Bednarczyk K, Celichowski G, Chodkowski M, Grobelny J, Ranoszek-Soliwoda K, Janicka M, Krzyzowska M   +7 more
core   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Biocompatible Iron Oxide Nanoparticles Display Antiviral Activity Against Two Different Respiratory Viruses in Mice [PDF]

Marta L DeDiego,1,* Yadileiny Portilla,2,* Neus Daviu,2 Darío López-García,1 Laura Villamayor,1 Paula Vázquez-Utrilla,1 Vladimir Mulens-Arias,2 Sonia Pérez-Yagüe,2 Aitor Nogales,3 Jesús G Ovejero,4 Alvaro Gallo-Cordova,4 Luis Enjuanes,1 Sabino ...
Mulens-Arias V, Veintemillas-Verdaguer S, Vázquez-Utrilla P, Nogales A, Pérez-Yagüe S, Daviu N, DeDiego ML, Morales MP, Ovejero JG, Villamayor L, Enjuanes L, Portilla Y, López-García D, Gallo-Cordova A, Barber DF   +14 more
core   +1 more source

Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses.

PLoS ONE, 2009
Tetherin (also known as BST2, CD317 or HM1.24) has recently been reported to inhibit a wide range of viruses. However, the antiviral mechanism of action of tetherin has not been determined.
Toshie Sakuma, Akira Sakurai, Jiro Yasuda   +2 more
doaj   +1 more source

DMS‐MaPseq and DREEM Analyses Implicate the Critical Role of RNA Structural Dynamics in Turnip Yellow Mosaic Virus Pathogenicity

Advanced Science, EarlyView.
RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu, Changhao Li, Chisimbily Onyia, Xindi Li, Xingxing Yan, Songxiao Zhong, Taerin Oh, Xiuren Zhang   +7 more
wiley   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source