Results 151 to 160 of about 250,897 (215)

Antiviral activity of Staphylococcus aureus V8 protease against bovine alphaherpesvirus-1 in vitro. [PDF]

J Vet Med Sci
Borjigin S, Nunomura Y, Nishifuji K, Mizutani T, Oba M.   +4 more
europepmc   +1 more source

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

Antiviral Activity of Liposomes Containing Natural Compounds Against CHIKV. [PDF]

Pharmaceutics
Calmon MF, Gusmão LA, Ruiz TFR, Campos GRF, Ayusso GM, Carvalho T, Bortolato IDVF, Conceição PJP, Taboga SR, Jardim ACG, Merits A, Rahal P, Tedesco AC.   +12 more
europepmc   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

A Flavonoid-Rich Extract of Scoparia dulcis L. Exhibits Antiviral Activity against Herpes Virus Type 1. [PDF]

Chem Biodivers
Jales FLML, Siqueira EMDS, Dantas-Medeiros R, de Araújo ERD, Alves JSF, Rocha HAO, Lopes NP, Ferreira LS, Tavares EA, Zucolotto SM.   +9 more
europepmc   +1 more source

Bemnifosbuvir: An HCV NS5B Inhibitor With Multiple Modes of Action

Clinical Pharmacology &Therapeutics, EarlyView.
Bemnifosbuvir (BEM) is a potent, pan‐genotypic inhibitor targeting the hepatitis C virus (HCV) NS5B polymerase. Its antiviral activity was evaluated in an ascending dose phase I clinical trial involving 30 patients treated once a day for 7 days. After treatment initiation, plasma HCV RNA declined in a biphasic manner with a mean reduction of 2.3 log10 ...
Carolin Zitzmann, Ruy M. Ribeiro, Aurélien Marc, Xiao‐Jian Zhou, Alan S. Perelson   +4 more
wiley   +1 more source

In Vitro Validation of Size-Dependent Antiviral Activity of <i>Phaeodactylum tricornutum</i>-Derived Peptide Fractions Against SARS-CoV-2. [PDF]

Mar Drugs
Cañedo-Figueroa DM, Márquez-Reyna BA, Santos-Mena AO, Calderón-Sandate DN, Lira-Hernández FI, Castañeda-Delgado JE, García-Herrera AC, Del Ángel RM, León-Juárez M, Valdez-Flores MA, López-Angulo G, Norzagaray-Valenzuela CD, Calderón-Zamora L, Cervantes-Bobadilla E, Osuna-Ramos JF, De Jesús-González LA.   +15 more
europepmc   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo, Vincenzo Patamia, Chiara Zagni, Antonio Rescifina, Giuseppe Floresta   +4 more
wiley   +1 more source

Correction: A hedgehog cathelicidin-derived peptide exhibits antiviral activity against herpes simplex virus type 1 infection. [PDF]

Front Microbiol
Deng E, Pei Y, Yuan K, Yang J, Cao SA, Yang X, Li G, Liang L, Jin L, Zhu T.   +9 more
europepmc   +1 more source

Circulating monocyte partitioning and its alteration in hematological chronic neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating monocyte partitioning refers to the relative quantification of the three main monocyte subsets in the peripheral blood, namely classical (cMo), intermediate (iMo), and non‐classical (ncMo) monocytes, as assessed by flow cytometry, a new nomenclature described 15 years ago.
Sihem Tarfi, Dorothée Selimoglu‐Buet, Ivan Sloma, Orianne Wagner‐Ballon, on behalf of the French group CytHem‐LMMC   +4 more
wiley   +1 more source