Results 121 to 130 of about 6,413,077 (257)

Experimental Medications Made with Сetraria islandica Showing Antiviral Activity against Influenza A Virus

Антибиотики и Химиотерапия
Background. To date, virologists have identified more than 25,000 influenza virus А serotypes, and their number will increase in the future. Therefore, the development of new antiviral drugs will always be relevant.The aim of the study is to obtain and ...
E. V. Makarevich, M. A. Protsenko, O. Yu. Mazurkov, E. I. Filippova, N. A. Mazurkova   +4 more
doaj   +1 more source

Indomethacin has a potent antiviral activity against SARS coronavirus

, 2006
Severe acute respiratory syndrome (SARS) is a newly emerging, highly transmissible and fatal disease caused by a previously unknown coronavirus (SARS-CoV).
Santoro, MG, Decaro, N, Ciucci, A, AMICI, CARLA, Buonavoglia, C, Castilletti, C, SANTORO, MARIA GABRIELLA, Chiappa, L, Capobianchi, MR, Di Caro, A, Martella, V, Amici, C   +11 more
core  

Structure-activity relationships of apio nucleosides as potential antiviral agents

, 2016
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio ...
정낙신
core   +1 more source

DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction

Advanced Science, EarlyView.
Protein function is represented as a dynamic conformational ensemble rather than a single static structure. A multi‐conformation geometric attention framework aligns, clusters, and learns representative states to capture residue‐ and ensemble‐level signals. Integrating structural dynamics improves interpretable protein‐NA binding prediction and reveals
Pengpai Li, Yiman Liu, Liya Liang, Rongming Liu   +3 more
wiley   +1 more source

Antiviral activity of CRDS on the four dengue virus serotypes.

, 2013
Antiviral activity of CRDS on the four dengue virus serotypes.
Subhash G. Vasudevan (175384), Naoki Yamamoto (200072), Sindhoora Bhargavi Gopala Reddy (407063), Lars Heinig (407066), Yoshiyuki Yoshinaka (407069), Tegshi Muschin (407065), Eng Eong Ooi (56879), Li Feng Zhang (261723), Takashi Yoshida (47738), Koji Ichiyama (407062), Nobuo Nomura (3114), Youichi Suzuki (407067), Wei Xin Chin (407064), Akihide Ryo (244201), Haraprasad Nanjundappa (407068)   +14 more
core   +1 more source

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Antiviral activity of propolis

, 2004
Propolis, a natural product of beehives, comprises a complex of chemicals, the most important being flavonoids, which are known to havw antiviral activities.
CERMELLI, Claudio, BERETTI, Francesca, Cenacchi V, QUAGLIO, Giampaola, Lonetti I, Bergamini F   +5 more
core  

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

The anti-papillomavirus activity of human and bovine lactoferricin

, 2007
Human papillomavirus (HPV) cause common warts, laryngeal papilloma and genital condylomata and is necessary for the development of cervical cancer.
Drobni, P, Näslund, Jonas,, Sunkari, VG, Sunkari, Vivekananda Gupta, Näslund, J, Jenssen, Håvard, Evander, Magnus,, Evander, M, Drobni, Peter,, Mistry, N, Mistry, Nitesh,, Jenssen, H   +11 more
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source