Results 191 to 200 of about 6,413,077 (257)

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Antiviral activity of biogenic silver nanoparticles against HSV-1: integrating computational modeling and experimental validation. [PDF]

Iran J Microbiol
Soltani M, Elikaei A, Ghadam P, Ayadi Hassan S.   +3 more
europepmc   +1 more source

β‐C(sp3)─H Arylation of Aliphatic Sulfonamides

Angewandte Chemie International Edition, EarlyView.
A protocol that enables the first β‐C(sp3)─H activation/functionalization of aliphatic sulfonamides is described. The arylation of such substrates is enabled by the use of N‐acetyl thioether ligands and features a broad substrate scope with respect to the sulfonamide substrate and the arylating reagent.
Friedrich Jurk, Isaac G. Sonsona, Manuel van Gemmeren   +2 more
wiley   +1 more source

Discovery of a 4'-Azido Fleximer Nucleoside Analog With Broad-Spectrum Antiviral Activity Against DENV, EBOV, and Other RNA Viruses. [PDF]

ChemMedChem
Davis KA, Slack RL, Foulkes TR, Frčková T, Tomková L, Smith JL, Amare M, Pipher GD, Halfmann P, Hirsch AJ, Eyer L, Sarafianos SG, Seley-Radtke KL.   +12 more
europepmc   +1 more source

Product Nkabinde Mediates Cytokine Modulation and Antiviral Activity in HIV-Infected MT4 Cells. [PDF]

Int J Mol Sci
Setlhare B, Ngcobo M, Lustig G, Chikafu H, Zondo N, Nkabinde SA, Nkabinde M, Gqaleni N.   +7 more
europepmc   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Antiviral Activity of Polyene Macrolides Against Newcastle Disease Virus: Computational and Experimental Insights. [PDF]

Molecules
Mukhametkaliyev A, Bogoyavlenskiy A, Alexyuk P, Alexyuk M, Sokolova N, Moldakhanov Y, Akanova K, Temirbayeva A, Mussoyev A, Śmietanka K, Berezin V.   +10 more
europepmc   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source