Results 201 to 210 of about 10,450,245 (405)

Transient Compound Treatment Induces a Multigenerational Reduction of Oxysterol-Binding Protein (OSBP) Levels and Prophylactic Antiviral Activity

, 2018
Brett L. Roberts, Zachary C. Severance, Ryan C. Bensen, Anh‐Tuan Le, Naga Rama Kothapalli, Juan I. Nuñez, Hong-Yan Ma, Si Wu, Shawna J. Standke, Zhibo Yang, William J. Reddig, Earl L. Blewett, Anthony W. G. Burgett   +12 more
openalex   +2 more sources

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Virucidal activity and the antiviral mechanism of acidic polysaccharides against Enterovirus 71 infectionin vitro [PDF]

, 2019
Zhihui Li, Bin Cui, Xiaowen Liu, Laicheng Wang, Qingjie Xian, Zhaoxi Lu, Shuntao Liu, Yin‐Guang Cao, Yueran Zhao   +8 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Development of a Biosafety Level 1 Cellular Assay for Identifying Small-Molecule Antivirals Targeting the Main Protease of SARS-CoV-2: Evaluation of Cellular Activity of GC376, Boceprevir, Carmofur, Ebselen, and Selenoneine [PDF]

Yasunori Fukumoto, Noriyuki Suzuki, Reina Hara, Yuki Tanaka, Yasumitsu Ogra   +4 more
openalex   +1 more source

Antiviral activity, pharmacokinetics and safety of the second-generation hepatitis B core inhibitor ABI-H2158 in Phase 1b study of patients with HBeAg-positive chronic hepatitis B infection

, 2020
Kosh Agarwal, Junqi Niu, Yanhua Ding, Edward Gane, Tuan Nguyen, Katia Alves, Marc Evanchick, Hany Zayed, Qi Huang, Steven Knox, Luisa M. Stamm, Richard J. Colonno, Tarek Hassanein, Dong Joon Kim, Young‐Suk Lim, Man‐Fung Yuen   +15 more
openalex   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

Antiviral Drugs and Interferon: The Molecular Basis of Their Activity

, 1984
Yechiel Becker, Julia Hadar
openalex   +2 more sources

Synthesis and in vitro Study of Antiviral and Virucidal Activity of Novel 2-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide Derivatives [PDF]

, 2011
Monika Wujec, Tomasz Plech, Agata Siwek, Barbara Rajtar, Małgorzata Polz‐Dacewicz   +4 more
openalex   +1 more source

Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity [PDF]

, 2021
Ulfert Rand, Sascha Young Kupke, Hanna Shkarlet, Marc D. Hein, Tatjana Hirsch, Pavel Marichal‐Gallardo, Luka Čičin‐Šain, Udo Reichl, Dunja Bruder   +8 more
openalex   +1 more source