Results 51 to 60 of about 10,107,380 (301)
Scientific Reports, 2020 The current coronavirus (COVID-19) pandemic is exacerbated by the absence of effective therapeutic agents. Notably, patients with COVID-19 and comorbidities such as hypertension and cardiac diseases have a higher mortality rate.
Junhyung Cho +6 more
semanticscholar +1 more source
In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]
, 2005 Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ +9 more
core +1 more source
Potential antiviral activity of metformin against human Adenovirus-7 [PDF]
Microbes and Infectious DiseasesBackground: Human adenovirus 7(HAdV-7) cause acute respiratory tract infections with high morbidity and mortality rates in children and immunocompromised adults. Metformin is a natural oral antihyperglycemic drug, that possesses antiviral activity.
Ibrahim Abdelwahab, Gihan ELBatouti
doaj +1 more source
Molecules, 2023 Adenoviruses are the major cause of ocular viral infections worldwide. Currently, there is no approved antiviral treatment for these eye infections. Cyclopentenylcytosine (CPE-C) is an antiviral that has demonstrated activity against more than 20 viruses.
Eric G. Romanowski +2 more
doaj +1 more source
MECHANISMS OF ANTIVIRAL ACTIVITY OF FLAVONOIDS [PDF]
Biotechnologia Acta, 2023 The article examines the multifaceted mechanisms underlying the antiviral activity of flavonoids, compounds widely distributed in the plant kingdom. The aim of the work was to review literature data on mechanisms of antiviral activity of flavonoids.
Golembiovska O.I. +4 more
doaj +1 more source
mBio, 2020 Repurposing existing, clinically approved, antiviral drugs as COVID-19 therapeutics is a rapid way to help combat the SARS-CoV-2 pandemic. Interferons (IFNs) usually form part of the body’s natural innate immune defenses against viruses, and they have ...
I. Busnadiego +7 more
semanticscholar +1 more source
Prophylactic antiviral activity of sulfated glycomimetic oligomers and polymers.
Journal of the American Chemical Society, 2020 In this work, we investigate the potential of highly sulfated synthetic glycomimetics to act as inhibitors of viral binding/infection. Our results indicate that both, long chain glycopolymers and short chain glycooligomers are capable of preventing viral
Laura Soria-Martinez +10 more
semanticscholar +1 more source
The antiviral RNAi response in vector and non-vector cells against orthobunya viruses [PDF]
, 2017 Background: Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and
Bausch, DG +9 more
core +5 more sources
Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID‐19
Clinical pharmacology and therapy, 2020 Azithromycin (AZ) is a broad‐spectrum macrolide antibiotic with a long half‐life and a large volume of distribution. It is primarily used for the treatment of respiratory, enteric, and genitourinary bacterial infections.
B. Damle +4 more
semanticscholar +1 more source
Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes [PDF]
, 2015 We have previously reported that stabilization of the G-quadruplex structures in the HIV-1 long terminal repeat (LTR) promoter suppresses viral transcription.
Botti, Silvia +10 more
core +1 more source