Results 81 to 90 of about 355,010 (330)

Functional Polymer Nanocomposites by Gas Aggregation Cluster Source and Initiated Chemical Vapor Deposition

Advanced Materials Technologies, EarlyView.
In this work, a gas aggregation cluster source and an initiated chemical vapor deposition are combined in a single vacuum reactor. With this setup polymer thin films can be combined with functional nanoparticles. As a proof‐of‐concept PTFE is combined with silver nanoparticles and tested in antibacterial, antiviral, and anticancer applications ...
Torge Hartig, Joschka Paulsen, Jonas Drewes, Asmaa T. Mohamed, Nasra F. Abdel Fattah, Cedric Hinrichs, Felix Pohl, Stefan Rehders, Ainura Aliyeva, Henning Wieker, Jörg Wiltfang, Salih Veziroglu, Samah A Loutfy, Oral Cenk Aktas, Alexander Vahl, Thomas Strunskus, Aydin Gülses, Amal Amin, Stefan Schröder, Franz Faupel   +19 more
wiley   +1 more source

SERINC Proteins Potentiate Antiviral Type I IFN Induction and Proinflammatory Signaling Pathways

Proceedings, 2020
T cell SERINC proteins were recently identified as human immunodeficiency virus (HIV) restriction factors that diminish viral infectivity by incorporation into virions.
Cong Zeng, Abdul A. Waheed, Tianliang Li, Jingyou Yu, Yi-Min Zheng, Jacob Yount, Haitao Wen, Eric O. Freed, Shan-Lu Liu   +8 more
doaj   +1 more source

Marine compounds and their antiviral activities

Antiviral Research, 2010
Available treatments for many infectious diseases are limited. In particular, diseases caused by viral pathogens have demonstrated the need for new medicines, due to the increasing appearance of resistance to these available treatments. Thousands of novel compounds have been isolated from various marine organisms and tested for pharmacological ...
Yuanan Lu, Jarred Yasuhara-Bell
openaire   +3 more sources

Double‐Sided Control of Product Type Preference in the Visible‐Light Initiated Reaction of 1,3‐Dicarbonyl Compounds with Alkenes

Advanced Synthesis &Catalysis, EarlyView.
Abstract The demonstrated light‐initiated addition of radicals formed on an active methylene group to styrene derivatives exhibits a product selectivity influenced by the presence of a protic solvent. Under protic conditions, the predominant products are branched compounds with the alkene moiety attached to the methylene group.
Małgorzata Pałyga, Jan Rzepiela, Sebastian Baś   +2 more
wiley   +1 more source

Fluorine‐Directed Automated Mannoside Assembly

Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023
Motivated by the importance of fluorination in drug discovery, fluorine‐directed automated glycan assembly (AFGA) is disclosed. This strategy leverages the C(sp3)−F bond at C2 to enable α‐stereocontrolled glycosylation that eliminates the reliance on O‐based directing groups.
Charlotte S. Teschers, Ryan Gilmour
wiley   +1 more source

Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses. [PDF]

PLoS ONE, 2009
Tetherin (also known as BST2, CD317 or HM1.24) has recently been reported to inhibit a wide range of viruses. However, the antiviral mechanism of action of tetherin has not been determined.
Toshie Sakuma, Akira Sakurai, Jiro Yasuda   +2 more
doaj   +1 more source

Asymmetric synthesis of highly substituted spiro[2H‐pyrrole‐2,3‐succinimide] derivatives by copper‐catalyzed post‐Ugi reactions

Advanced Synthesis &Catalysis, Accepted Article.
Herein we present a novel one‐por methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism supported by density functional theory (DFT) calculations, where a hydrogen radical ...
Maria Garcia Valverde, Javier Gómez-Ayuso, Israel Carreira-Barral, Roberto Quesada   +3 more
wiley   +1 more source

Evaluation of the duration of new nasal drug interferon α-2b activity in an experimental model system

Virology Journal
This study aimed To develop an adequate system for assessing the duration of IFN antiviral activity in the nasal cavity of animals and to study the antiviral activity of a new IFN drug in the form of a gel in comparison with the known spray form. Methods
N. Bezdieniezhnykh, O. Lykhova, G. Borshchevskiy, Ye. Kruglov, M. Borshchevska   +4 more
doaj   +1 more source

Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs [PDF]

, 2011
By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are virtually unknown.
arxiv   +1 more source

Virucidal Efficacy of Laser-Generated Copper Nanoparticle Coatings Against Model Coronavirus and Herpesvirus [PDF]

arXiv, 2023
High-efficiency antiviral surfaces can be effective means to fight against viral diseases such as the recent Covid-19 pandemic. Copper and copper oxides, as well as their nanoparticles (Cu NPs) and coatings, are among the effective antiviral materials having internal and external biocidal effects on viruses.
arxiv