Results 211 to 220 of about 3,627,015 (399)

Cefuroxime axetil dosing regimens and probability of target attainment in adults and children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefuroxime axetil exists in several dosage forms for oral administration, and is indicated for treatment of respiratory, genitourinary, skin and soft tissue infections. Evolving patterns of bacterial susceptibility, expressed as increasing minimum inhibitory concentrations (MICs), warrant monitoring of antibiotic efficacy.
Sven C. van Dijkman, Praveen Kamble, Jerzy A. Kowalski, Oscar Della Pasqua   +3 more
wiley   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, EarlyView.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

Recombinant Green Fluorescent Protein-Expressing Human Cytomegalovirus as a Tool for Screening Antiviral Agents [PDF]

, 2000
Manfred Marschall, Martina Freitag, Sigrid Weiler, Gabriele Sorg, Thomas Stamminger   +4 more
openalex   +1 more source

Transcriptomic functional characterization of recombinant adeno‐associated virus producing cell line adapted to suspension‐growth

Biotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus (rAAV) is a widely used delivery vehicle in gene therapy. A scalable production technology is essential for its wide clinical applications. We have taken a synthetic biology approach to generate HEK293‐based cell lines which harbor integrated genetic elements encoding essential AAV and adenoviral helper ...
Han‐Jung Kuo, Prahalad Srinivasan, Yu‐Chieh Lin, Min Lu, Carissa Rungkittikhun, Qi Zhang, Wei‐Shou Hu   +6 more
wiley   +1 more source

Cationic Porphyrins as Antimicrobial and Antiviral Agents in Photodynamic Therapy. [PDF]

Curr Issues Mol Biol, 2023
Savelyeva IO, Zhdanova KA, Gradova MA, Gradov OV, Bragina NA.   +4 more
europepmc   +1 more source

Cytomegalovirus Infection Decreases Expression of Thrombospondin‐1 and ‐2 in Cultured Human Retinal Glial Cells: Effects of Antiviral Agents [PDF]

, 2000
Jindřich Činátl, Martina Bittoova, Stefan Margraf, Jens‐Uwe Vogel, Jaroslav Činátl, Wolfgang Preiser, Hans Wilhelm Doerr   +6 more
openalex   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents

, 1992
Nell S. Lurain, Kim D. Thompson, E W Holmes, G. Sullivan Read   +3 more
openalex   +1 more source

Synthesis and evaluation of novel bioconjugates as antiviral agents [PDF]

, 2000
Geeta Watal, V. Shukla, Krishna Misra
openalex   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zen, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source