Results 81 to 90 of about 3,623,509 (414)
, 2009 Antiviral agents are drugs approved in the USA by the Food and Drug Administration (FDA) for the treatment or control of viral infections. Available antiviral agents mainly target stages in the viral life cycle. The target stages in the viral life cycle are; viral attachment to host cell, uncoating, synthesis of viral mRNA, translation of mRNA ...
Paintsil, E., Cheng, Yung-Chi
openaire +1 more source
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core +1 more source
Benzothiazoles as potential antiviral agents
The Journal of pharmacy and pharmacology, 2020 The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current ...
Y. Asiri +4 more
semanticscholar +1 more source
BMC Infectious Diseases, 2022 Background In HCV-infected patients with advanced liver disease, the direct antiviral agents-associated clinical benefits remain debated. We compared the clinical outcome of patients with a previous history of decompensated cirrhosis following treatment ...
Georges-Philippe Pageaux +37 more
doaj +1 more source
Progression of Antiviral Agents Targeting Viral Polymerases
Molecules, 2022 Viral DNA and RNA polymerases are two kinds of very important enzymes that synthesize the genetic materials of the virus itself, and they have become extremely favorable targets for the development of antiviral drugs because of their relatively conserved
Siqi Peng +3 more
doaj +1 more source
Virucidal Efficacy of Laser-Generated Copper Nanoparticle Coatings Against Model Coronavirus and Herpesvirus [PDF]
arXiv, 2023 High-efficiency antiviral surfaces can be effective means to fight against viral diseases such as the recent Covid-19 pandemic. Copper and copper oxides, as well as their nanoparticles (Cu NPs) and coatings, are among the effective antiviral materials having internal and external biocidal effects on viruses.
arxiv
Link between allosteric signal transduction and functional dynamics in a multi-subunit enzyme: S-adenosylhomocysteine hydrolase [PDF]
J. Am. Chem. Soc. (2011) vol. 133, 19807-19815, 2011 S-adenosylhomocysteine hydrolase (SAHH), a cellular enzyme that plays a key role in methylation reactions including those required for maturation of viral mRNA, is an important drug target in the discovery of antiviral agents. While targeting the active site is a straightforward strategy of enzyme inhibition, evidences of allosteric modulation of ...
arxiv +1 more source
Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors [PDF]
, 2018 Indolylarylsulfones are a potent class of human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors. In this review, the structure activity relationship (SAR) studies to improve the profile of sulfone L-737,126 discovered by ...
Famiglini, V., Silvestri, R.
core +1 more source
Phytochemicals as Antiviral Agents: Recent Updates
Plant-derived Bioactives, 2020 The epidemic of viral diseases is a global concern, mandating an urgent need of most promising antivirals. Some of the viral diseases can be cured by approved antiviral drugs, but for others still do not have any vaccines or drugs available.
R. Ghildiyal +4 more
semanticscholar +1 more source
PaccMann$^{RL}$ on SARS-CoV-2: Designing antiviral candidates with conditional generative models [PDF]
ICML Workshop on Computational Biology 2020, 2020 With the fast development of COVID-19 into a global pandemic, scientists around the globe are desperately searching for effective antiviral therapeutic agents. Bridging systems biology and drug discovery, we propose a deep learning framework for conditional de novo design of antiviral candidate drugs tailored against given protein targets.
arxiv