Results 51 to 60 of about 951,212 (251)

Defense Management concepts improving Indonesian Maritime Security [PDF]

, 2016
This study aimed to analyze the concept of Indonesian Defence Management in the 21st century in the context of Indonesian Maritime Security and to determine the readiness of defence management capabilities in facing threats.
Barnas, Rayanda, Purwanto, Purwanto, Saragih, Herlina JR   +2 more
core   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Antiviral protein genetic markers physiologically induced in cucumber by beneficial microbes against cucumber mosaic virus

Jurnal Hama dan Penyakit Tumbuhan Tropika
Plant antiviral-induced protein markers provide important indicators of the effectiveness of plant defense responses against viral infection, supporting early detection, disease monitoring, and evaluation of antiviral strategies.
Allam Arafat Megahed, Badawy Abdelsalam Othman, Hassan Mohamed Mohamed Masoud, Mohamed Salah Eldin Helmy, Khaled Abdelfattah El-Dougdoug   +4 more
doaj   +1 more source

The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling

Viruses, 2014
Interferons (IFNs) activate the first lines of defense against viruses, and promote innate and adaptive immune responses to viruses. We report that the immediate early 1 (IE1) protein of human cytomegalovirus (HCMV) disrupts signaling by IFNγ.
Bindu Raghavan, Charles H. Cook, Joanne Trgovcich   +2 more
doaj   +1 more source

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

Cell Death and Disease, 2022
Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic.
Rebekka Karlowitz, Megan L. Stanifer, Jens Roedig, Geoffroy Andrieux, Denisa Bojkova, Marco Bechtel, Sonja Smith, Lisa Kowald, Ralf Schubert, Melanie Boerries, Jindrich Cinatl, Steeve Boulant, Sjoerd J. L. van Wijk   +12 more
doaj   +1 more source

Natural Variation in Resistance to Virus Infection in Dipteran Insects

Viruses, 2018
The power and ease of Drosophila genetics and the medical relevance of mosquito-transmitted viruses have made dipterans important model organisms in antiviral immunology.
William H. Palmer, Finny S. Varghese, Ronald P. van Rij   +2 more
doaj   +1 more source

Auxin response factors (ARFs) differentially regulate rice antiviral immune response against rice dwarf virus.

PLoS Pathogens, 2020
There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown.
Qingqing Qin, Guangyao Li, Lian Jin, Yu Huang, Yu Wang, Chunhong Wei, Zhihong Xu, Zhirui Yang, Haiyang Wang, Yi Li   +9 more
doaj   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Turnip crinkle virus coat protein subverts DRB7-mediated compensatory RNAi through ubiquitin-proteasome-dependent degradation

Plant Communications
The evolutionary arms race between plants and viruses hinges on the sophistication of host defense mechanisms and viral counter-defenses. RNA silencing serves as a fundamental antiviral strategy in plants, primarily mediated by Dicer-like (DCL) proteins ...
Kunxin Wu, Yan Fu, Pingjuan Zhao, Qiuxian Xie, Shuxia Li, Yadan Wu, Xueting Liu, Ping Gan, Mengbin Ruan, Xiuchun Zhang   +9 more
doaj   +1 more source

An OLD protein teaches us new tricks: prokaryotic antiviral defense. [PDF]

Reporting in Nature Communications, Huo and colleagues provide three-dimensional structures of a bacterial immune defense system called Gabija. This work builds on recently published structural and functional studies and contributes strong evidence that ...
Ednacot, Eirene, Morehouse, Benjamin
core   +1 more source