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Pharmacology of Antiviral Drugs. [PDF]
VirusesAntiviral drug therapy has significantly evolved over the past four decades, partly driven by improved understanding of viral replication mechanisms but also advances in pharmacology and formulation technologies [...]
Martin DE.
europepmc +4 more sources
Antiviral Drugs in Influenza [PDF]
International Journal of Environmental Research and Public Health, 2022 Flu is a serious health, medical, and economic problem, but no therapy is yet available that has satisfactory results and reduces the occurrence of these problems. Nearly 20 years after the registration of the previous therapy, baloxavir marboxil, a drug with a new mechanism of action, recently appeared on the market.
Magdalena Świerczyńska +2 more
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Hyperbranched Polymers: Recent Advances in Photodynamic Therapy against Cancer
Pharmaceutics, 2023 Hyperbranched polymers are a class of three-dimensional dendritic polymers with highly branched architectures. Their unique structural features endow them with promising physical and chemical properties, such as abundant surface functional groups ...
Jie Chen, Yichuan Zhang
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Antiviral drugs and antiviral drug resistance [PDF]
Current Opinion in Virology, 2011 Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Donald M, Coen, Richard J, Whitley
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Broad-Spectrum Antivirals and Antiviral Drug Combinations [PDF]
Viruses, 2022 Viral diseases consistently pose a substantial economic and public health burden worldwide [...]
Valentyn Oksenych, Denis E. Kainov
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Frontiers in Cellular Neuroscience, 2022 N6-methyladenosine (m6A) is the most abundant post-transcription modification, widely occurring in eukaryotic mRNA and non-coding RNA. m6A modification is highly enriched in the mammalian brain and is associated with neurological diseases like Alzheimer ...
Fangfang Zhang +5 more
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Cancers, 2018 Epstein–Barr virus (EBV) infects up to 95% of the adult human population, with primary infection typically occurring during childhood and usually asymptomatic. However, EBV can cause infectious mononucleosis in approximately 35–50% cases when infection occurs during adolescence and early adulthood.
Pagano, Joseph S. +2 more
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iScience, 2022 Summary: L3MBTL2 is a crucial component of ncPRC1.6 and has been implicated in transcriptional repression and chromatin compaction. However, the repression mechanism of L3MBTL2 and its biological functions are largely undefined.
Hua Huang +8 more
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Cell & Bioscience, 2021 Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging ...
Xuechai Chen +6 more
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Journal of Integrative Neuroscience, 2022 As a catechol isoquinoline, salsolinol (Sal) is widely distributed in mammalian brains, and is increased in the cerebrospinal fluid (CSF) and urine of Parkinsonian patients. Sal can be metabolized to N-methyl-salsolinol (NM-Sal), an MPP+-like neurotoxin,
Qianqian Xiong +7 more
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