Results 51 to 60 of about 4,215,496 (299)

Neuropsychiatric Effects of Antiviral Drugs

Cureus, 2020
The adverse events of antiviral drugs are dose-dependent and often reversible. The nervous system is often affected and to date, many studies have been published regarding the central nervous system toxicity of antiviral agents.
N. Zareifopoulos, M. Lagadinou, A. Karela, O. Kyriakopoulou, D. Velissaris   +4 more
semanticscholar   +1 more source

The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer

Molecules
The aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral absorption.
Sheng Chang, Qiang Yang, Jiahuan Liu, Li Yin, Jihong Han, Lanlan Zong, Xiaohui Pu   +6 more
doaj   +1 more source

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Journal of Experimental & Clinical Cancer Research, 2023
Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression.
Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang, Jianing Liu, Wei Zhang, Tao Li, Hanjing Niu, Guochen Bao, Chaojie Wang, Peng George Wang, Jiajia Wang, Xia Li, Taotao Zou, Songqiang Xie   +14 more
doaj   +1 more source

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus [PDF]

, 2018
Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against ...
Andrew V Stachulski, Brian M Eklov, Chandrakala Pidathala, Eleanor C Row, Giuseppe Belardo, J Edward Semple, Jean-Francois Rossignol, La Frazia S, M Gabriella Santoro, Mazhar Iqbal, Neil G Berry, Paul M O'Neill, Podlogar BL, Rossignol JF, Rossignol JF, Sara Piacentini, Sarah A Allman, Simone La Frazia   +17 more
core   +1 more source

Modeling the Worldwide Spread of Pandemic Influenza: Baseline Case and Containment Interventions [PDF]

, 2007
We present a study of the worldwide spread of a pandemic influenza and its possible containment at a global level taking into account all available information on air travel.
Alain Barrat, Alain-Jacques Valleron, Alessandro Vespignani, Alison P Galvani, Marc Barthelemy, Vittoria Colizza   +5 more
core   +5 more sources

Evaluation of 19 antiviral drugs against SARS-CoV-2 Infection

bioRxiv, 2020
The global pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCoV) has prompted multiple clinical trials to jumpstart search for anti-SARS-CoV-2 therapies from existing drugs, including those with reported in vitro ...
Shufeng Liu, C. Lien, Prabhuanand Selvaraj, Tony T. Wang   +3 more
semanticscholar   +1 more source

Design of C 1-symmetric tridentate ligands for enantioselective dearomative [3 + 2] annulation of indoles with aminocyclopropanes

Nature Communications, 2023
Chiral polycyclic indolines are widely present in natural products and have become the focus of extensive synthetic efforts. Here, we show the catalytic asymmetric dearomative [3 + 2] annulation of indoles with donor-acceptor aminocyclopropanes to ...
Hai-Xia Wang, Chun Yang, Bai-Yu Xue, Ming-Sheng Xie, Yin Tian, Cheng Peng, Hai-Ming Guo   +6 more
doaj   +1 more source

Prediction of baseline oral microbiota for clinical classification post Omicron variant of SARS-CoV-2 infection

Scientific Reports
Oral microbiota is related to the severity and recovery of SARS-CoV-2 infection. This study aims to predict clinical classification after SARS-CoV-2 infection using oral microbiota before infection.
Junyi Sun, Shanshuo Liu, Daming Wang, Jia Yu, Bowen Liu, Hong Luo, Feng Gao, Yawen Zou, Ying Sun, Haiyu Wang, Xueping Wang, Yongjian Zhou, Lei Li, Zhongwen Wu, Zujiang Yu, Zhigang Ren   +15 more
doaj   +1 more source

Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health

Frontiers in Cellular Neuroscience
Due to the increased crewed spaceflights in recent years, it is vital to understand how the space environment affects human health. A lack of gravitational force is known to risk multiple physiological functions of astronauts, particularly damage to the ...
Zihan Li, Jiarui Wu, Tianyuan Zhao, Yiyun Wei, Yajing Xu, Zongjian Liu, Xiaoqiong Li, Xuechai Chen   +7 more
doaj   +1 more source

Mechanistic insights into post-translational modifications in hepatic fibrosis: pathogenic roles and therapeutic potentials

Journal of Translational Medicine
Hepatic fibrosis, a critical progression in liver disease, has been widely studied. While the activation of stellate cells and the accumulation of extracellular matrix components are recognized as key mechanisms, additional research is necessary to ...
Xiwen Bai, Zhihan Liu, Xianbin Li, Ranran Sun, Zujiang Yu   +4 more
doaj   +1 more source