Results 51 to 60 of about 4,144,524 (396)

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer

Molecules
The aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral absorption.
Sheng Chang, Qiang Yang, Jiahuan Liu, Li Yin, Jihong Han, Lanlan Zong, Xiaohui Pu   +6 more
doaj   +1 more source

Design of C 1-symmetric tridentate ligands for enantioselective dearomative [3 + 2] annulation of indoles with aminocyclopropanes

Nature Communications, 2023
Chiral polycyclic indolines are widely present in natural products and have become the focus of extensive synthetic efforts. Here, we show the catalytic asymmetric dearomative [3 + 2] annulation of indoles with donor-acceptor aminocyclopropanes to ...
Hai-Xia Wang, Chun Yang, Bai-Yu Xue, Ming-Sheng Xie, Yin Tian, Cheng Peng, Hai-Ming Guo   +6 more
doaj   +1 more source

Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents [PDF]

, 2014
Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes.
A Owsianka, A Sigal, Aleem Siddiqui, Arvind H. Patel, AS Lok, AW Tarr, B Bartolini, B Sainz Jr, C Hezode, C Lee, C Nathan, C Sarrazin, CL Brimacombe, CM Lange, CT Jones, D Masson, D Trono, EJ Gane, Eric Soulier, F Kuonen, F Poordad, F Poordad, Fei Xiao, François Habersetzer, G Koutsoudakis, H Kwon, H Yan, H Zhu, Heidi Barth, I Fofana, I Fofana, I Fofana, IA Abela, IM Jacobson, Isabel Fofana, J Grove, J Lupberger, J Witteveldt, J Zhong, Jens Bukh, JG McHutchison, JM Gottwein, JM Gottwein, JM Pawlotsky, JM Pawlotsky, JM Pawlotsky, JM Timpe, L Rong, L Zona, Laura Heydmann, LW Meredith, MB Zeisel, MB Zeisel, Michel Doffoël, Mirjam B. Zeisel, MN Zahid, MS Sulkowski, MT Catanese, N Shi, O Lenz, P Zhong, PM Trembling, Q Sattentau, S Haid, T Pietschmann, T Pietschmann, T Wakita, Thomas F. Baumert, TJ Liang, TK Scheel, V Soriano, VD Cataldo, ZY Keck   +72 more
core   +6 more sources

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel.

Journal of the American Medical Association (JAMA), 2020
Importance Data on the use of antiretroviral drugs, including new drugs and formulations, for the treatment and prevention of HIV infection continue to guide optimal practices.
M. Saag, R. Gandhi, J. Hoy, R. Landovitz, M. Thompson, P. Sax, Davey M. Smith, C. Benson, S. Buchbinder, C. del Rio, J. Eron, G. Fätkenheuer, H. Günthard, J. Molina, D. M. Jacobsen, P. Volberding   +15 more
semanticscholar   +1 more source

The Pharmacological Potential of Mushrooms [PDF]

, 2005
This review describes pharmacologically active compounds from mushrooms. Compounds and complex substances with antimicrobial, antiviral, antitumor, antiallergic, immunomodulating, anti-inflammatory, antiatherogenic, hypoglycemic, hepatoprotective and ...
Jülich, Wolf-Dieter, Lindequist, Ulrike, Niedermeyer, Timo H. J.   +2 more
core   +3 more sources

Evaluation of 19 antiviral drugs against SARS-CoV-2 Infection

bioRxiv, 2020
The global pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or 2019-nCoV) has prompted multiple clinical trials to jumpstart search for anti-SARS-CoV-2 therapies from existing drugs, including those with reported in vitro ...
Shufeng Liu, C. Lien, Prabhuanand Selvaraj, Tony T. Wang   +3 more
semanticscholar   +1 more source

Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors. [PDF]

, 2017
The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions across the PB2 protein sequence ...
Kukol, A., Kukol, A., Patel, H., Patel, H.   +3 more
core   +3 more sources

Antiviral drugs –

, 2012
This review of the 2010 publications on antiviral drugs covers drugs active against cytomegalovirus, herpesviruses, hepatitis viruses, the human immunodeficiency virus (nucleoside analogue reverse transcriptase inhibitors, nucleotide analogue reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors ...
Gert U. van Zyl, Gert U. van Zyl, Wolfgang Preiser, Stephen N.J. Korsman, Stephen N.J. Korsman, Stephen N.J. Korsman, Louise Nutt, Monique Andersson   +7 more
openaire   +5 more sources

Constructive strategies for drug delivery systems in antivirus disease therapy by biosafety materials

Biosafety and Health, 2022
Due to the coronavirus disease 2019 (COVID-19) pandemic, the development of antiviral drugs has attracted increasing attention. Clinical antiviral drugs show weak solubility, low bioavailability, adverse side effects, or only limited targets.
Li Wang, Zhaoshuo Wang, Lingzhi Cao, Kun Ge   +3 more
doaj   +1 more source