Results 131 to 140 of about 2,451,260 (295)

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Detection and characterization of antiviral-resistant viruses during the influenza season of 2024–25

Microbiology Spectrum
During the high severity season of 2024–25, CDC with public health partners sequenced and analyzed genomes of >10,000 influenza viruses for antiviral resistance markers.
Mira C. Patel, Ha T. Nguyen, Philippe Noriel Q. Pascua, Mercedes Lopez-Esteva, Chloe Champion, Vasiliy P. Mishin, Han Di, Kristine Lacek, Marie K. Kirby, Allen Bateman, Maureen Sullivan, Susan Trow, Jennifer Laplante, Kirsten St. George, Benjamin Rambo-Martin, Angiezel Merced-Morales, Alicia Budd, Rebecca J. Kondor, Charles T. Davis, Larisa V. Gubareva   +19 more
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Association of nucleos(t)ide analogue treatment history with mortality in HBV-DNA-positive HBV-ACLF: a multicenter cohort study

Frontiers in Immunology
Background and aimsHepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is associated with high short- and long-term mortality. Prior nucleos(t)ide analogue (NA) treatment history, particularly treatment withdrawal and virological ...
Liping Shen, Zhiqiang Jin, Fang Wei, Jie Li, Sijing Li, Xiaohao Wang, Hu Li, Shan Zhong   +7 more
doaj   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Prevalence of genotypic resistance among antiretroviral drug-naive HIV-1 infected patients in Belgium

, 2001
This is the author’s version of a work accepted for publication by International Medical Press. Changes resulting from the publishing process, including peer review, editing and formatting, might not be reflected in this document.
Stuyver, L., Verhofstede, C., De Cabooter, Nancy, Miller, Kurt, Fransen, K., MARISSENS, D, De Cabooter, N., Zissis, G., DESMYTER, J, Verhofstede, ChrisGE328010008305200000-0002-0645-1174F49657CE-F0ED-11E1-A9DE-61C894A0A6B4, Van Ranst, M., Van Vaerenbergh, Kristien, Verhofstede, Chris, VAN RANST, M, MILLER, K, Declercq, C., Debaisieux, Laurent, Vandamme, Anne-Mieke, FRANSEN, K, DECLERCQ, C, Stuyver, Lieven, Vaira, D., Van Vaerenbergh, K., Maes, B., SPRECHER, S, DE CLERCQ, E, Sprecher-Goldberger, Suzanne, Vaira, Dolores, STUYVER, L, Desmyter, Jan, Muyldermans, Gaëtan, DEBAISIEUX, L, Declercq, Christophe, MUYLDERMANS, G, ZISSIS, G, VAIRA, D, DESMET, K, MAES, B, Marissens, D., Muyldermans, G., Fransen, Katrien, Sprecher, S., Desmyter, J., De Clercq, Eric, Zissis, Georges, Miller, K., Marissens, Denise, Desmet, K., VAN VAERENBERGH, K, Van Ranst, Marc, De Clercq, E., Vandamme, A. M., Debaisieux, L., Maes, Bart, VANDAMME, AM, Desmet, Koen, De Cabooter, NancyUZGent00018154105580100099824897740595565600953130-F0EE-11E1-A9DE-61C894A0A6B4   +56 more
core  

Antiviral strategies to control calicivirus infections

, 2010
Caliciviridae are human or non-human pathogenic viruses with a high diversity. Some members of the Caliciviridae, i.e. human pathogenic norovirus or rabbit hemorrhagic disease virus (RHDV), are worldwide emerging pathogens.
Mattevi, Andrea, Gould, Ernest, Gebhardt, Julia, Neyts, Johan, Bergmann, Mirko, Rohayem, Jacques, Unge, Torsten,, Tucker, Paul, Hilgenfeld, Rolf   +8 more
core   +1 more source

Antiviral resistance in influenza viruses

Cellular and Molecular Biology, 2023
Luis, Márquez Domínguez, Kevin, Márquez Matla, Julio, Reyes Leyva, Verónica, Vallejo Ruíz, Gerardo, Santos López   +4 more
openaire   +2 more sources

Beyond Probiotics: Postbiotics for Healthy Aquaculture

Advanced Science, EarlyView.
This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas, Delin Xu, Igor V. Popov, Kayque Ordonho Carneiro, Nilufar Arashovna Elova, Gullola Amirovna Bekmurodova, Dildora Amindjanovna Amirsaidova, Astghik Pepoyan, Shakhlo Mirjamalovna Miralimova, Oleg V. Mitrokhin, Liubov S. Sichel, John Tagg, Svetoslav Dimitrov Todorov   +12 more
wiley   +1 more source

An ATP‐Driven N Protein–DDX21 Molecular Switch Dynamically Controls SARS‐CoV‐2 RNA G‐Quadruplex Heterogeneity

Advanced Science, EarlyView.
An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng, Li‐Yan Zhai, Jie Jin, Qiu‐Ying Chen, Hang Fu, Xue‐Qian Sun, Ying Lu, Hui Li, Xi‐Miao Hou   +8 more
wiley   +1 more source