Results 251 to 260 of about 2,451,260 (295)
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Nature Microbiology, 2019
Baloxavir marboxil (BXM) represents a promising advance in antiviral chemotherapies for influenza infections. Identification of transmissible BXM-resistant strains in Japan may hit pause on widespread adoption of this therapy and could lead to revision of surveillance practices for emerging viruses.
Karen A. Kormuth, Seema S. Lakdawala
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Baloxavir marboxil (BXM) represents a promising advance in antiviral chemotherapies for influenza infections. Identification of transmissible BXM-resistant strains in Japan may hit pause on widespread adoption of this therapy and could lead to revision of surveillance practices for emerging viruses.
Karen A. Kormuth, Seema S. Lakdawala
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A perspective on antiviral resistance
Journal of Clinical Virology, 2009More than 25 years after the licensure of aciclovir and then penciclovir, followed by their respective prodrugs valaciclovir and famciclovir, cases of clinically relevant resistance to these drugs in immunocompetent individuals remain very rare. The aim of this review is to focus on the mechanism of action of these anti HSV drugs and then briefly ...
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Resistance of Viruses to Antiviral Drugs
Annual Review of Medicine, 1991In recent years, substantial advances in antiviral therapy have been made; however, in the immunocompromised host, antiviral drug resistance is becoming an issue of increasing clinical importance. Understanding the mechanism of action of antiviral agents, especially those used to treat herpesvirus infections, may enable us to design new therapeutic ...
A G, Freifeld, J M, Ostrove
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2008
There are two classes of anti-influenza drugs - one class targets the M2 proton channel whereas the other class targets the surface glycoprotein neuraminidase.
Alan J. Hay +2 more
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There are two classes of anti-influenza drugs - one class targets the M2 proton channel whereas the other class targets the surface glycoprotein neuraminidase.
Alan J. Hay +2 more
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New Antivirals and Antiviral Resistance
2004The field of antiviral therapy is relatively new. Whereas the first antibiotics were available in the 1940s, the first antiviral agent (idoxuridine) was not licensed until the 1960s. Furthermore, the number of antiviral agents available to clinicians today pale in comparison to the number of antibacterial agents.
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Modeling Antiviral Resistance in Plants
2012The goal of this chapter is to describe in simple terms how the use of ordinary differential equation (ODE) modeling, in conjunction with experimentation, can be utilized to improve our understanding of the dynamics of gene silencing and virus resistance in plants.
Robert S, Anderssen, Peter M, Waterhouse
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Drug Resistance in Antiviral Therapy
Clinics in Liver Disease, 2010The introduction of nucleos(t)ide analog therapy has seen the emergence of antiviral drug resistance, which has become the main factor limiting the long-term application of these antiviral agents for patients with chronic hepatitis B. The prevention of resistance requires the adoption of strategies that effectively control virus replication and exploit
Stephen, Locarnini, Scott, Bowden
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Annals of the New York Academy of Sciences, 1990
Antiviral drug resistance is an area of increasing importance in acquired immunodeficiency syndrome (AIDS), not only in terms of the human immunodeficiency virus (HIV), but also opportunistic pathogens such as herpes simplex virus (HSV) and human cytomegalovirus (CMV).
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Antiviral drug resistance is an area of increasing importance in acquired immunodeficiency syndrome (AIDS), not only in terms of the human immunodeficiency virus (HIV), but also opportunistic pathogens such as herpes simplex virus (HSV) and human cytomegalovirus (CMV).
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Antivirals and resistance: influenza virus
Current Opinion in Virology, 2011Influenza causes annual epidemics of respiratory viral infections are associated with significant morbidity and mortality. Influenza vaccines have been shown to reduce the risk of infection and mitigate against some of the virus' sequellae. Likewise, two classes of antivirals, the adamantanes (amantadine and rimantadine) and the neuraminidase ...
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Hepatitis B antivirals and resistance
Current Opinion in Virology, 2013Antiviral therapy for chronic hepatitis B (CHB) has improved the outcome of patients. However, due to the multiple selection pressures of different nucleos(t)ide analogue, drug resistant HBV variants have emerged. Because of the arrangement of overlapping reading frames in HBV genome, these variants not only have clinical implications such as drug ...
Uma, Devi, Stephen, Locarnini
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