Results 121 to 130 of about 798,677 (318)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Associations between PACAP levels and psychophysiological indicators of fear and arousal in adults with posttraumatic stress symptoms

Journal of Mood and Anxiety Disorders
Posttraumatic stress disorder (PTSD) is associated with heightened fear responding and decreased fear regulation, as demonstrated with psychophysiological measures (e.g., autonomic function) and circulating biomarkers of stress, such as pituitary ...
Antonia V. Seligowski, Kevin J. Clancy, Eylül Akman, Michael Lewis, Victor May, Caitlin Ravichandran, Sydney A. Jobson, Daniel E. Bradford, Sayamwong E. Hammack, William A. Carlezon, Jr., Kerry J. Ressler, Scott L. Rauch, Isabelle M. Rosso   +12 more
doaj   +1 more source

Prevalence of perceived depression and anxiety among hypertensives attending imo specialist hospital owerri, Nigeria

, 2020
Background: Depression is a burdensome disease of global importance, and although prevalent, it is mostly undiagnosed in patients with hypertension. Anxiety is another significant factor associated with increased Blood Pressure and is an independent ...
Alvan Ifeanyi Okene, Ugonma Winnie Dozie, Uchenna Launa Iwumune, Maureen Maduagwu, Leo clinton Chukwu, Angela Juliet Uka-Okali, Chidiebere Peter Echieh, Uchenna Ewelike, Emmanuel Adeyemi Odumeru, Queen KenechukwuDozie, Ekundayo Babajide Otuyelu, Uchenna Francis Agu, Somtochukwu Mercy Orji, Chikere Ifeanyi Casmir Ebirim   +13 more
core   +1 more source

Different gene sets contribute to different symptom dimensions of depression and anxiety [PDF]

, 2012
Although many genetic association studies have been carried out, it remains unclear which genes contribute to depression. This may be due to heterogeneity of the DSM-IV category of depression.
Hartman, C.A., van Veen, Tineke, Goeman, Jelle J., Tineke van Veen, Brenda W.J.H. Penninx, Snieder, Harold; id_orcid, Nolte, Ilja M., Goeman, J.J., Monajemi, R., Ramin Monajemi, Jelle J. Goeman, Zitman, Frans G., Penninx, B.W.J.H., Wardenaar, K.J., Nolte, I.M., Hartman, Catharina A., Klaas J. Wardenaar, Monajemi, Ramin, Snieder, Harold, Penninx, Brenda W. J. H., Harold Snieder, Snieder, H., Catharina A. Hartman, Ilja M. Nolte, Nolte, Ilja M.; id_orcid, Frans G. Zitman, Zitman, F.G., Wardenaar, Klaas J., Veen, T. van, van Veen, T.   +29 more
core   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Measuring Financial Anxiety

, 2012
There is a scarcity of information concerning the emotional aspects of financial management. Two studies were conducted to evaluate the measurement of conscious and intuitive emotional anxiety toward one's personal finances.

core   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Longitudinal Cross-Lagged Relationships of Complex Post-Traumatic Stress Disorder, Depression, and Anxiety Among Adolescents and Emerging Adults With Childhood Bullying Victimization Experiences

Background: Individuals who have experienced bullying victimization often develop symptoms of complex post-traumatic stress disorder (CPTSD), depression, and anxiety, with these symptoms mutually influencing one another.
Liu, Mingxiao, Liu, Aiyi, Wu, Xinchun, Liu, Sihan, Xu, Boya   +4 more
core   +1 more source