Results 141 to 150 of about 798,677 (318)

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Posttraumatic Stress Disorder-Related Differences in Neural Connectivity Among Female Trauma Survivors

Biological Psychiatry Global Open Science
Background: Posttraumatic stress disorder (PTSD) is a debilitating condition that disproportionately impacts females. Prior research indicates that males with PTSD exhibit hypoconnectivity of frontal brain regions measured with resting ...
Natalie C. Noble, Mohammad S.E. Sendi, Julia B. Merker, Samantha R. Linton, Theresa K. Webber, Russell T. Toll, Amit Etkin, Wei Wu, Kerry J. Ressler, Antonia V. Seligowski   +9 more
doaj   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Affect Regulation and Treatment for Depression and Anxiety through Art: Theoretical Ground and Clinical Issues [PDF]

, 2014
Advances in neuroscience research have shown that depression and anxiety are closely related to affect regulation, the emotional processes that work within the brain system. This paper reviews two major areas of affect regulation. The first area accounts
Nan, JKM, Ho, RTH
core  

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Program evaluation of internet-delivered cognitive behavioral treatments for anxiety and depression in a digital clinic

Journal of Mood and Anxiety Disorders
SilverCloud and THIS WAY UP (TWU) are two internet-delivered cognitive-behavioral therapy (iCBT) programs that have demonstrated effectiveness for anxiety and depression, yet little is known about their comparative effectiveness.
Alexandra L. Silverman, IreLee Ferguson, Jacqueline R. Bullis, Harris Bajwa, Sara Mei, Courtney Beard   +5 more
doaj   +1 more source

The impact of environmental experiences on symptoms of anxiety and depression across the life span

, 2011
Symptoms of anxiety and depression are relatively stable over time. Can this stability be explained by genetic influences, or is it caused by the long-lasting effects of accumulating environmental experiences?
Eaves, Lindon J., Loken, EK, Loken, E.K., Reynolds, C., Chandra Reynolds, Kenneth S. Kendler, Loken, Erik K., Gardner, C.O., Lindon J. Eaves, Charles O. Gardner, Gardner, Charles O., Middeldorp, Christel M., Erik K. Loken, Reynolds, C, Boomsma, D, Middeldorp, CM, Gardner, CO, Boomsma, Dorret, Lichtenstein, P., Reynolds, Chandra, Kendler, Kenneth S., Lichtenstein, P,, Pedersen, Nancy L., Eaves, L.J., Pedersen, N.L., Paul Lichtenstein, Kendler, KS, Christel M. Middeldorp, Pedersen, NL, Boomsma, D.I., Silberg, Judy, Judy Silberg, Silberg, J., Dorret Boomsma, Nancy L. Pedersen, Boomsma, D.I.; id_orcid, Middeldorp, C.M., Silberg, J, Lichtenstein, Paul, Kendler, K.S., Eaves, LJ   +40 more
core   +1 more source

Extreme Weather Events and Consumer Food Responses

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study investigates consumer food responses to Hurricanes Helene and Milton, which affected a swath of the Southeastern U.S. in 2024. Using representative consumer survey data from six affected states, we analyze 10 distinct food responses classified into ex ante and ex post responses, and examine their associations with food insufficiency
Ahmad Zia Wahdat, Joseph Balagtas
wiley   +1 more source