Results 81 to 90 of about 798,677 (318)

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Cognitive Behavioral Therapy for Youth With Childhood‐Onset Lupus: A Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective Our objective was to determine the feasibility and acceptability of the Treatment and Education Approach for Childhood‐Onset Lupus (TEACH), a six‐session cognitive behavioral intervention addressing depressive, fatigue, and pain symptoms, delivered remotely to individual youth with lupus by a trained interventionist.
Natoshia R. Cunningham, Thea Senger‐Carpenter, Jocelyn Zuckerman, Michelle Adler, Mallet R. Reid, Ashley Danguecan, Luana Flores Pereira, Sarah I. Mossad, Samantha L. Ely, Khalid Abulaban, Elizabeth A. Kessler, Natalie Rosenwasser, Tamar B. Rubinstein, Ekemini A. Ogbu, Emily A. Smitherman, Alaina Miller, Taylor Abounader, Elizabeth Ross, Livie Timmerman, Dhriti Sharma, Jennifer N. Stinson, Stacy Allen, Kabita Nanda, Tala El Tal, Deborah M. Levy, Linda T. Hiraki, Hermine I. Brunner, Mathew Reeves, Steven J. Pierce, Andrea Knight   +29 more
wiley   +1 more source

Differences in High-Frequency Connectivity Among Large-Scale Functional Networks Linked to Major Depressive Disorder and Treatment-Resistant Depression

Biological Psychiatry Global Open Science
Background: Major depressive disorder (MDD) and treatment-resistant depression (TRD) have each been characterized by altered neural connectivity largely associated with the triple model of the default mode (DMN), frontoparietal (FPN), and salience (SN ...
Ty Lees, Sarah E. Woronko, Mohan Li, Jason N. Scott, Jr., Manuel Kuhn, Shiba M. Esfand, Mario Bogdanov, Brian W. Boyle, Samantha R. Linton, Lauren R. Borchers, Peter Zhukovsky, Courtney Miller, Paula Bolton, Shuang Li, Robert C. Meisner, Diego A. Pizzagalli   +15 more
doaj   +1 more source

Anxiety and depression symptomatology in adult siblings of disabled individuals: The role of perceived parenting, attachment, personality traits and disability types [PDF]

, 2011
Objectives: (1) To ascertain whether adult siblings of disabled individuals are more prone to anxiety and depression symptomatology than a closely matched control group.
O'Neill, Linda P.
core  

Childhood and adolescent anxiety and depression: Beyond heritability

, 2010
Objective: To review the methodology of behavior genetics studies addressing research questions that go beyond simple heritability estimation and illustrate these using representative research on childhood and adolescent anxiety and depression.
Franic, S., Sanja Franić, Franic, Sanja, Dolan, C.V., Middeldorp, Christel M., Conor V. Dolan, Ligthart, Lannie, Christel M. Middeldorp, Boomsma, D.I., Boomsma, Dorret I., Dorret I. Boomsma, Ligthart, L., Lannie Ligthart, Dolan, Conor V., Boomsma, D.I.; id_orcid, Middeldorp, C.M., Ligthart, L.; id_orcid   +16 more
core   +1 more source

Anxiety and Depression [PDF]

The Primary Care Companion For CNS Disorders, 2000
Properly diagnosing and treating patients with anxiety, depression, or both is a challenging aspect of practicing medicine in the primary care setting. Patients often present with somatic complaints rather than classic psychiatric symptoms. In addition, there is significant overlap between anxiety and depression in this patient population.
openaire   +2 more sources

Addressing Economic Insecurities Can Improve Patient‐Reported Outcomes in Lupus

Arthritis Care &Research, EarlyView.
Objective Economic insecurities, such as food, housing, transportation, and financial challenges, are modifiable risk factors and influence patient‐reported outcomes (PROs) in systemic lupus erythematosus (SLE). We examined the following: (1) associations between economic insecurities and PROs, and (2) the impact of screening and addressing economic ...
Jay Patel, Tripti Singh, Meredith Ingersoll, Shelby Gomez, Amanda Weber, Sarah E. Panzer, Sancia Ferguson, Christie M. Bartels, Shivani Garg   +8 more
wiley   +1 more source

Population-level normative models reveal race- and socioeconomic-related variability in cortical thickness of threat neurocircuitry

Communications Biology
The inequitable distribution of economic resources and exposure to adversity between racial groups contributes to mental health disparities within the United States.
Nathaniel G. Harnett, Negar Fani, Grace Rowland, Poornima Kumar, Saige Rutherford, Lisa D. Nickerson   +5 more
doaj   +1 more source

Ketamine Improves Anhedonic Phenotypes Across Species: Translational Evidence From the Probabilistic Reward Task

Biological Psychiatry Global Open Science
Background: Ketamine is increasingly used as a therapeutic option for treatment-resistant depression (TRD) due to its rapid antidepressant properties; however, the mechanisms underlying these effects remain elusive. Preclinical evidence suggests ketamine
Mario Bogdanov, Jason N. Scott, Jr., Shiba M. Esfand, Brian W. Boyle, Ty Lees, Mohan Li, Sarah E. Woronko, Samantha R. Linton, Amaya R. Jenkins, Courtney Miller, Shuang Li, Paula Bolton, Daniela B. Radl, Thomas J. Kornecook, Robert C. Meisner, Brian D. Kangas, Diego A. Pizzagalli   +16 more
doaj   +1 more source