Results 131 to 140 of about 1,211,565 (358)

Associations between PACAP levels and psychophysiological indicators of fear and arousal in adults with posttraumatic stress symptoms

Journal of Mood and Anxiety Disorders
Posttraumatic stress disorder (PTSD) is associated with heightened fear responding and decreased fear regulation, as demonstrated with psychophysiological measures (e.g., autonomic function) and circulating biomarkers of stress, such as pituitary ...
Antonia V. Seligowski, Kevin J. Clancy, Eylül Akman, Michael Lewis, Victor May, Caitlin Ravichandran, Sydney A. Jobson, Daniel E. Bradford, Sayamwong E. Hammack, William A. Carlezon, Jr., Kerry J. Ressler, Scott L. Rauch, Isabelle M. Rosso   +12 more
doaj   +1 more source

The effect of esketamine in patients with treatment‐resistant depression with and without comorbid anxiety symptoms or disorder

, 2021
Ella Daly, Ibrahim Turkoz, Giacomo Salvadore, Maggie Fedgchin, Dawn F. Ionescu, H. Lynn Starr, Stephane Borentain, Madhukar H. Trivedi, Michael E. Thase, Jaskaran Singh   +9 more
openalex   +1 more source

APPLICATION OF ACUPUNCTURE IN EMOTIONAL DISORDER PATHOLOGIES: Stress, Anxiety and Depression – Bibliographic Review [PDF]

, 2022
Maria Luiza Nunes, Mariele Sousa Meireles, Maria Eduarda Santos, Rosana Soares Lisboa Silva, Wendel Batista Carreiro, Yara Silva, Izabel da Silva Fonseca, Tiago da Silva Brito   +7 more
openalex   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Exploring individual differences in fear extinction in male and female mice: insights from HPA axis, microbiota, and transcriptomics

Translational Psychiatry
Exposure to traumatic life events may compromise physical and mental health of specific subjects. While some individuals extinguish fear appropriately, others exhibit an inefficient and persistent fear response, with remarkable differences between sexes.
Marc Ten-Blanco, María Ponce-Renilla, Inmaculada Pereda-Pérez, Cristina Izquierdo-Luengo, Carlo Bressa, Olga Zafra, Rosa María Tolón, Fernando Berrendero   +7 more
doaj   +1 more source

Sleep problems in pain patients entering tertiary pain care: the role of pain-related anxiety, medication use, self-reported diseases, and sleep disorders

, 2021
Teemu Miettinen, Jaana Sverloff, Olli-Pekka Lappalainen, Steven J. Linton, Kirsi Sipilä, Eija Kalso   +5 more
openalex   +1 more source

Ecologically‐Valid Emotion Signatures Enhance Mood Disorder Diagnostics

Advanced Science, EarlyView.
This study identifies ecologically‐valid Divergent Emotional Functional Networks (DEFN), derived from dynamic functional connectivity during naturalistic movie watching. The DEFN reliably enhances diagnostic accuracy for mood disorders, including major depressive and bipolar disorders, demonstrating strong reproducibility across demographic factors and
Shuyue Xu, Linling Li, Ting Luo, Gan Huang, Li Zhang, Benjamin Becker, Zhen Liang   +6 more
wiley   +1 more source

Attention guidance augmentation of virtual reality exposure therapy for social anxiety disorder: a pilot randomized controlled trial

, 2022
Mikael Rubin, Karl Muller, Mary Hayhoe, Michael J. Telch   +3 more
openalex   +2 more sources

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source