Results 91 to 100 of about 73,505 (352)

Anxiolytic and sedative-like effects of flavonoids from Tilia Americana var. Mexicana: GABAergic and serotonergic participation

open access: yes, 2016
Introduction. The inflorescences of Tilia americana var. mexicana are used as an infusion in Mexican traditional medicine due to their tranquilizing effects; however, pharmacological and phytochemical studies of the leaves are lacking. Objective. In this
E. Aguirre-Hernández   +4 more
semanticscholar   +1 more source

Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism‐Like Behaviors in a Valproic Acid Induced Male Mouse Model

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated whether Ginsenoside Rg1 (Rg1) alleviates autism‐like behaviors in mice prenatally exposed to valproic acid (VPA) via Sirt2/Foxo1 signaling. Pregnant C57BL/6J mice received a single intraperitoneal injection of VPA (600 mg/kg) on embryonic Day 12.5 to establish an autism model.
Fan‐Xu Song   +8 more
wiley   +1 more source

Multimorbidity and use of hypnotic and anxiolytic drugs: cross-sectional and follow-up study in primary healthcare in Iceland

open access: yesBMC Family Practice, 2016
BackgroundThe prevalence of multimorbidity is increasing worldwide, presumably leading to an increased use of medicines. During the last decades the use of hypnotic and anxiolytic benzodiazepine derivatives and related drugs has increased dramatically ...
K. Linnet   +6 more
semanticscholar   +1 more source

Efficacy and Safety of Intratympanic Botulinum Toxin Injection on Middle Ear Myoclonic Tinnitus

open access: yesThe Laryngoscope, EarlyView.
Intratympanic Botulinum toxin (IT‐BTX) injection appears to be an effective and safe treatment for MEMT, significantly reducing tinnitus‐related symptoms without complications. In a retrospective study of 57 patients, THI scores and VAS measures for loudness, awareness, annoyance, and life impact improved significantly over 6 months.
Ji Hyung Lim   +8 more
wiley   +1 more source

Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis

open access: yesFrontiers in Pharmacology, 2016
We describe different neuropharmacological effects of Verbena officinalis crude extract (Vo.Cr). Pentylenetetrazole (PTZ)-induced seizures, elevated plus maze, light–dark box (LDB), open field and thiopental-induced sleeping test models were employed to ...
Abdul Waheed Khan   +2 more
semanticscholar   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud   +2 more
wiley   +1 more source

Preserved Thermoregulation in Huntington's Disease: Insights from an Observational Case–Control Study

open access: yesMovement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Thermoregulation is critical for preventing hyperthermia during physical activity. In Huntington's disease (HD), research on possible thermoregulatory alterations has received little attention. Objectives We aimed to investigate and compare skin temperature differences before and after exercise between HD patients and healthy ...
Lucía Simón‐Vicente   +7 more
wiley   +1 more source

Analgesic, Anxiolytic and Anaesthetic Effects of Melatonin: New Potential Uses in Pediatrics

open access: yesInternational Journal of Molecular Sciences, 2015
Exogenous melatonin is used in a number of situations, first and foremost in the treatment of sleep disorders and jet leg. However, the hypnotic, antinociceptive, and anticonvulsant properties of melatonin endow this neurohormone with the profile of a ...
L. Marseglia   +6 more
semanticscholar   +1 more source

The Feasibility and Practical Utility of Virtual Visits for Patients with Parkinson's Disease in Different World Regions

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Overcoming existing access barriers is crucial for better‐specialized health care of patients with Parkinson's disease (PD). Objective The aim of the study was to compare the access and visit quality/acceptability between in‐office and virtual telemedicine visits.
Álvaro García‐Bustillo   +11 more
wiley   +1 more source

Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1–42) rat model of Alzheimer’s disease

open access: yesBehavioral and Brain Functions, 2015
BackgroundPiper nigrum L. (Piperaceae) is employed in traditional medicine of many countries as analgesic, antiinflammatory, anticonvulsant, antioxidant, antidepressant and cognitive-enhancing agent.
L. Hritcu   +5 more
semanticscholar   +1 more source

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