Results 71 to 80 of about 88,094 (292)

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl‐Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk   +13 more
wiley   +1 more source

The impact of single‐dose trazodone administration on plasma endogenous adrenocorticotropic hormone and serum cortisol concentrations in healthy dogs

Journal of Veterinary Internal Medicine
Background Conditions affecting the hypothalamic‐pituitary‐adrenal (HPA) axis are common in dogs. Testing the function of the HPA axis includes measurement of endogenous adrenocorticotropic hormone (eACTH) and performance of an adrenocorticotropic ...
Morgan Brown, Tekla Lee‐Fowler, Ellen N. Behrend, Megan Grobman   +3 more
doaj   +1 more source

Clinical effects of central antagonist of cholecystokinin-1 receptors GB-115 in patients with Generalized Anxiety Disorder

European Psychiatry, 2022
Introduction The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily.
O. Dorofeeva, T. Syunyakov, M. Metlina, N. Ivashkina   +3 more
doaj   +1 more source

Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety [PDF]

, 2014
Although gene-environment interactions are known to significantly influence psychopathology related disease states, only few animal models cover both the genetic background and environmental manipulations.
Chekmareva, N., Czibere, L., Diepold, R., Landgraf, R., Naik, R., Sotnikov, S.   +5 more
core   +2 more sources

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Effects of Chlordiazepoxide on Predator Odor-Induced Reductions of Playfulness in Juvenile Rats

, 2010
The extent to which a non-sedative dose of chlordiazepoxide (CDP) is able to modify the behavioral responses toward a predator odor was assessed in juvenile rats.
DeBrouse, Lauren M., Siviy, Stephen M., Steets, Courtney L.   +2 more
core   +1 more source

Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study [PDF]

, 2012
Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer ...
A J Lee, C Bond, C Burton, C Burton, DR Cox, E Martin-Merino, F Desplenter, F Hansen, G Laekeman, G Rait, J Madden, JC Holland, JL Roffman, K Lefevre, KC Yung, L Hodges, M Miovic, M Sharpe, M Vahdaninia, M Watson, MB First, MJ Massie, NF Khan, P Lockhart, P Murchie, PP Roy-Byrne, R Morris, R Munoz-Arroyo, RA Lewis, S Simoens, S Wein, SB Patten, TL Deshields, V Strong   +33 more
core   +1 more source

Latent Trajectories of Body Mass Index and Depressive Symptoms in Inpatients With Anorexia Nervosa: Predictors and Outcomes

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Inpatient treatment aimed at weight restoration and psychiatric stabilization is often required for individuals with anorexia nervosa (AN). This study aimed to identify distinct trajectories of change in body mass index (BMI) and depressive symptoms during inpatient treatment, examine clinical predictors and outcomes, and test ...
Matteo Martini, Mie Sedoc Jørgensen, Cristiano Dani, Anne Bryde Christensen, Magnus Sjögren, Nadia Micali   +5 more
wiley   +1 more source

Behavioral Profiles of Genetically Selected Aggressive and Nonaggressive Male Wild House Mice in Two Anxiety Tests [PDF]

, 2000
Artificially selected aggressive (SAL) and non-aggressive (LAL) male house mice were tested in a hexagonal tunnel maze and light–dark preference (LD) box to determine if the bidirectional selection for aggressive behavior leads to a coselection for ...
Hof, Maleen,, Hogg, Sandy,, Koolhaas, Jaap,, Ruiter, Anne de,, Sluyter, Frans,, Steimer, Thierry,, Würbel, Hanno,   +6 more
core   +2 more sources

Real‐world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2‐q13.1 duplication and deletion syndromes: A multicenter study

Epilepsia Open, EarlyView.
Abstract This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2‐q13.1 duplication or deletion syndromes (15q‐DDS), including 12 with 15q duplication syndrome (dup15q) and 10 with Angelman syndrome (AS). Median (interquartile range [IQR]) age at CBD initiation was 14.5
Emanuele Cerulli Irelli, Adolfo Mazzeo, Marco Perulli, Georgia Ramantani, Domenica Battaglia, Irene Bagnasco, Erica Cognolato, Pasquale Striano, Susanna Negrin, Alberto Danieli, Paolo Bonanni, Francesca F. Operto, Carlo Di Bonaventura, Antonietta Coppola, Alessandro Orsini   +14 more
wiley   +1 more source