Results 91 to 100 of about 47,485 (252)

Variation in 90‐day substance use disorder‐related acute care events across United States opioid treatment programs: A Medicaid claims analysis

Addiction, EarlyView.
Abstract Background and aims Creating and tracking quality measures has improved outcomes in many areas of healthcare; however, quality measures specific to opioid treatment programs (OTPs) have not yet been developed. Based on the success seen in other fields, introducing quality measures in OTPs should help enhance positive outcomes and decrease ...
Barrett Wallace Montgomery, Tami L. Mark, Thanh Lu, William N. Dowd, Dylan DeLisle, Kathryn N. Burke, Daniel H. Barch, Gary A. Zarkin   +7 more
wiley   +1 more source

Predicting high‐risk novel benzodiazepines: A surveillance study of novel benzodiazepine detections and a case series of bromazolam exposures in New South Wales, Australia

Addiction, EarlyView.
Abstract Background and aims Novel benzodiazepines are increasingly detected in poisonings. Their relative toxicities remain poorly defined, complicating public health responses. Bromazolam has emerged in recent reports of severe poisoning. We sought a method to identify higher‐risk novel benzodiazepines, and to describe the clinical effects of ...
Emily Z. G. Sansoni, Janette L. Smith, Christine A. Harvey, Vanessa Shaw, Christopher Ewers, Ingrid Berling, Thanjira Jiranantakan, Jared Brown, Darren M. Roberts   +8 more
wiley   +1 more source

Acute Cutaneous Kava Toxicity: A Multicentre Case Series From South Australia

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Kava (piper methysticum) is a traditional beverage of Pacific Island communities which in 2021, re‐entered the Australian market, primarily promoted as an anxiolytic ‘wellness’ product. Emerging cases of acute kava toxicity have occurred since, characterised by a distinctive cutaneous morphology, with or without systemic manifestations.
Zoe Lee, Kristian Stefani, Karolina Kerkemeyer, Annabel Stevenson   +3 more
wiley   +1 more source

Menopausal status at the age of 46: Its association with depressive and anxiety symptoms and morbidity in women—A northern Finland birth cohort 1966 study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Women who are perimenopausal or menopausal at age 46 have a higher risk of anxiety and depressive symptoms than premenopausal women. Early‐onset menopause highlights the need for mental health support during and after the menopausal transition. Abstract Introduction The incidence of several morbidities increases during the menopausal transition ...
Tiia Saarinen, Susanna M. Savukoski, Paula Pesonen, Jouko Miettunen, Maarit Niinimäki   +4 more
wiley   +1 more source

The TOP‐GERD Trial: Comparative Efficacy of Tegoprazan Versus Pantoprazole in the Treatment of Erosive Oesophagitis in a Non‐Asian Population

Alimentary Pharmacology &Therapeutics, EarlyView.
In this randomized, double‐blind trial in Mexican adults with erosive oesophagitis, tegoprazan did not significantly improve the primary 4‐week ITT healing endpoint versus pantoprazole (88.9% vs. 79.4%; p = 0.33), but produced faster symptom improvement. Encouraging per‐protocol and severe‐oesophagitis findings warrant confirmation.
José M. Remes‐Troche, Luis Raúl Valdovinos‐García, C. Prakash Gyawali, José Luis Vargas‐Basurto, Carlos Alberto Reyes‐Medina, Gisselle Vanessa González‐Hernández, A. Rafael Bernal Mendez, H. H. Barragán Cordova, Pablo Thomas‐Dupont, Peter Grube‐Pagola   +9 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Prevalence of binge eating disorder symptoms and associated characteristics in Danish adults with type 2 diabetes: A cross‐sectional study

Diabetic Medicine, EarlyView.
Abstract Aims Coexistence of binge eating disorder (BED) and type 2 diabetes is linked to poor health outcomes, but data on the prevalence and clinical profile of BED symptoms remain limited and inconsistent. We estimated the prevalence of BED symptoms and examined their associated clinical characteristics in Danish adults with type 2 diabetes ...
Pernille Fiil Nybo, Sidsel Louise Domazet, Michael Einar Røder, Jakob Linnet   +3 more
wiley   +1 more source