Results 51 to 60 of about 47,485 (252)
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
A Portrait of Anxiety and Depression in Parkinson's Disease: Prevalence, Clinical Correlates, and Treatment Gaps. [PDF]
Mov Disord Clin PractAbstract Background Non‐motor symptoms (NMS), specifically anxiety and depression are major drivers of disability in Parkinson's disease (PD). Prevalence estimates remain inconsistent because of differences in population samples, diagnostic criteria, and symptom overlap, contributing to underdiagnosis and undertreatment.
Schmidt M +4 more
europepmc +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai +12 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Medication use during breastfeeding is common, yet data on drug transfer into breast milk and infant exposure remain limited. This study describes real‐world requests concerning medication compatibility with breastfeeding managed by the Lyon pharmacovigilance center over five years.
Blandine Bertin +8 more
wiley +1 more source
Pharmacogenetics Governance for Youth Mental Health: A Scoping Review of Policy Across 13 Countries
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacogenetics (PGx) testing could improve psychotropic prescribing for children and young people, yet youth‐specific policy guidance remains scarce. This review characterizes the international PGx policy landscape for youth mental health across 13 countries.
Prosper Mandela Amaltinga Awuni +6 more
wiley +1 more source
Navigating the Radical Oxo‐Functionalization of Alkenes Toward Ketones
European Journal of Organic Chemistry, EarlyView.Straightforward access to complex ketones in a single synthetic step: This Review surveys the latest advances in three‐component alkene 1,2‐oxo‐functionalizations. The opportunities unlocked by the so‐called single‐electron (1e–) logic, including access to a broad pool of radical precursors and carbonyl oxygen atom sources, are highlighted.
Mattia Lepori +3 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective In temporal lobe epilepsy (TLE), patients often present with neurobehavioral comorbidities encompassing affective and cognitive difficulties. Whereas the latter have been related to atypical connectivity of mesiotemporal and frontotemporal circuits, the brain basis of affective symptoms remains incompletely understood.
Fatemeh Fadaie +4 more
wiley +1 more source
European Eating Disorders Review, EarlyView.ABSTRACT Background Enhanced Cognitive Behaviour Therapy (CBT‐E) has demonstrated effectiveness in adolescents with anorexia nervosa (AN) and atypical anorexia nervosa (AAN); however, there is limited knowledge about factors that influence treatment outcome.
Daniel Wilson +10 more
wiley +1 more source
Future Postharvest and Food, EarlyView.The various citrus wastes, including the citrus fruit peels, pulp remaining after extraction of juice, and seeds, are the sources of bioactive compounds. The waste parts of oranges, lemons, limes, grapefruits, and mandarins contain the bioactive compounds, flavonoids, ascorbic acid, essential oils, and carotenoids.
Monika +4 more
wiley +1 more source
Antidepressant-Like Effects of n-Butylidenephthalide Using In Vivo and In Silico Approaches
PharmaceuticalsBackground: The plant-derived compound n-butylidenephthalide (BP) is an isobenzofuranone that has shown neuropharmacological effects on preclinical models of Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis.
María Leonor González-Rivera +9 more
doaj +1 more source