Results 31 to 40 of about 88,094 (292)

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Frontiers in Pharmacology, 2022
Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism.
Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima   +18 more
doaj   +1 more source

Associations between anxiety, body mass index, and sex hormones in women [PDF]

, 2019
Background: Several studies have shown a positive association between anxiety and obesity, particularly in women. We aimed to study whether sex hormone alterations related to obesity might play a role in this association.
Bae, Y., Ceglarek, U., Engel, C., Enzenbach, C., Glaesmer, H., Hinz, A., Kratzsch, J., Luck, T., Pabst, A., Riedel-Heller, S., Sacher, J., Stanik, J., Stanikova, D., Thiery, J., Wirkner, K.   +14 more
core   +2 more sources

Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition

Frontiers in Pharmacology, 2022
Hochuekkito (HET) is a Kampo medicine used to treat postoperative and post-illness general malaise and decreased motivation. HET is known to regulate immunity and modulate inflammation.
Soichiro Ushio, Yudai Wada, Mizuki Nakamura, Daiki Matsumoto, Kota Hoshika, Shoya Shiromizu, Naohiro Iwata, Satoru Esumi, Makoto Kajizono, Yoshihisa Kitamura, Yoshihisa Kitamura, Toshiaki Sendo   +11 more
doaj   +1 more source

Qualitative phytochemicals and pharmacological properties analysis of methanol extract of Tabernaemontana pauciflora leaves

Journal of Advanced Biotechnology and Experimental Therapeutics, 2021
The methanol extract of the leaves of Tabernaemontana pauciflora (METP) was screened to investigate the semi-qualitative phytochemical, in vivo anti-depressant, anxiolytic and in vitro thrombolytic activities.
Anowar Hossen, Mohammad Arman, Syed Al Jawad Sayem, Mohammad Rifat Alam Maruf, Md. Ahsan Ullah, Mohammad Nazmul Islam, Naureen Banu, Najmul Alam, Shahenur Alam Sakib   +8 more
doaj   +1 more source

Comparative Study of Piper sylvaticum Roxb. Leaves and Stems for Anxiolytic and Antioxidant Properties Through in vivo, in vitro, and in silico Approaches

Biomedicines, 2020
Piper sylvaticum Roxb. is traditionally used by the indigenous people of tropical and subtropical countries like Bangladesh, India, and China for relieving the common cold or a variety of chronic diseases, such as asthma, chronic coughing, piles ...
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kama, Md. Obyedul Kalam Azad, Kazi Asfak Ahmed Chowdhury, Mohammad Shah Hafez Kabir, Shaibal Das Gupta, Md. Ashiqur Rahman Chowdhury, Young Seok Lim, Dong Ha Cho   +9 more
doaj   +1 more source

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

Pharmaceuticals, 2021
Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of ...
Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D Clark, Scott Runyon   +10 more
doaj   +1 more source

Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity

Biomedicines, 2023
(1) Background: Adiponectin is an adipocyte-secreted hormone that has antidepressant- and anxiolytic-like effects in preclinical studies. Here, we investigated the antidepressant- and anxiolytic-like effects of sub-chronic treatment with AdipoRon, an ...
Douglas A. Formolo, Thomas H. Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S. Kranz, Suk-Yu Yau   +6 more
doaj   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats

Foods
Due to the health benefits of polyphenols and dietary fiber in combating mental disorders, we hypothesized that a polyphenol- and dietary fiber-enriched soup (RJ6601) would improve mental wellness in a rat model of middle-aged women.
Rujikan Chaisanam, Jintanaporn Wattanathorn, Wipawee Thukham-mee, Nawanant Piyavhatkul, Pongsatorn Paholpak   +4 more
doaj   +1 more source

Effects of psychotropic agents on extinction of lever-press avoidance in a rat model of anxiety vulnerability

Frontiers in Behavioral Neuroscience, 2014
Avoidance and its perseveration represent key features of anxiety disorders. Both pharmacological and behavioral approaches (i.e. anxiolytics and extinction therapy) have been utilized to modulate avoidance behavior in patients.
Xilu eJiao, Xilu eJiao, Xilu eJiao, Kevin D. Beck, Kevin D. Beck, Kevin D. Beck, Amanda L. Stewarts, Ian M. Smith, Ian M. Smith, Catherine E. Myers, Catherine E. Myers, Catherine E. Myers, Richard J Servatius, Richard J Servatius, Richard J Servatius, Kevin C.H. Pang, Kevin C.H. Pang, Kevin C.H. Pang   +17 more
doaj   +1 more source