Results 31 to 40 of about 47,485 (252)

Effects of psychotropic agents on extinction of lever-press avoidance in a rat model of anxiety vulnerability

Frontiers in Behavioral Neuroscience, 2014
Avoidance and its perseveration represent key features of anxiety disorders. Both pharmacological and behavioral approaches (i.e. anxiolytics and extinction therapy) have been utilized to modulate avoidance behavior in patients.
Xilu eJiao, Xilu eJiao, Xilu eJiao, Kevin D. Beck, Kevin D. Beck, Kevin D. Beck, Amanda L. Stewarts, Ian M. Smith, Ian M. Smith, Catherine E. Myers, Catherine E. Myers, Catherine E. Myers, Richard J Servatius, Richard J Servatius, Richard J Servatius, Kevin C.H. Pang, Kevin C.H. Pang, Kevin C.H. Pang   +17 more
doaj   +1 more source

Unravelling the Biological Activities of the Byttneria pilosa Leaves Using Experimental and Computational Approaches

Molecules, 2020
Byttneria pilosa is locally known as Harijora, and used by the native hill-tract people of Bangladesh for the treatment of rheumatalgia, snake bite, syphilis, fractured bones, elephantiasis and an antidote for poisoning. The present study was carried out
Mifta Ahmed Jyoti, Niloy Barua, Mohammad Shafaet Hossain, Muminul Hoque, Tahmina Akter Bristy, Shabnur Mahmud, Kamruzzaman, Md. Adnan, Md. Nazim Uddin Chy, Arkajyoti Paul, Mir Ezharul Hossain, Talha Bin Emran, Jesus Simal-Gandara   +12 more
doaj   +1 more source

Erratum to: Comparing the effectiveness of clomipramine and fluoxetine in dogs with anxiety-related behaviours

Veterinary Evidence
The original article was published in Veterinary Evidence Vol 9, Issue 1 (2024): https://doi.org/10.18849/ve.v9i1.679 In the original version of the article the contributions of one of the authors, Christopher Minami, were listed as "Investigation ...
Olivia Williamson, Valery Varela, Christopher Minami, Juliana Tom, Elizabeth Powell, Jeffrey W. Norris   +5 more
doaj   +1 more source

Intervention in Neuropsychiatric Disorders by Suppressing Inflammatory and Oxidative Stress Signal and Exploration of In Silico Studies for Potential Lead Compounds from Holigarna caustica (Dennst.) Oken leaves

Biomolecules, 2020
Holigarna caustica (Dennst.), a popular plant used in folk medicine in Bangladesh, is often used by the local folk practitioner to treat a variety of chronic diseases.
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kamal, Kazi Asfak Ahmed Chowdhury, Md. Atiar Rahman, A. S. M. Ali Reza, Md. Moniruzzaman, Satyajit Roy Rony, Mst. Samima Nasrin, Md. Obyedul Kalam Azad, Cheol Ho Park, Young Seok Lim, Dong Ha Cho   +12 more
doaj   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Synthesis and Pharmacological Evaluation of Novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole Derivatives as Promising Anxiolytic and Analgesic Agents

Molecules, 2021
A number of novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole derivatives 2 were obtained by alkylation mainly in the 1H-tautomeric form of 2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole or its 8,9-dimethyl-substituted analog 4 ...
Dmitriy V. Maltsev, Alexander A. Spasov, Pavel M. Vassiliev, Maria O. Skripka, Mikhail V. Miroshnikov, Andrey N. Kochetkov, Nataliya V. Eliseeva, Yuliya V. Lifanova, Tatyana A. Kuzmenko, Lyudmila N. Divaeva, Anatolii S. Morkovnik   +10 more
doaj   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs

Journal of Veterinary Internal Medicine, 2019
Background Noise phobia is a common behavior problem in dogs for which there are limited treatment options. Objective To evaluate the efficacy and safety of imepitoin in comparison to placebo for the control of anxiety and fear associated with noise ...
Odilo Engel, Hanns Walter Müller, Rebecca Klee, Bradley Francke, Daniel Simon Mills   +4 more
doaj   +1 more source

Evaluation of the Anxiolytic and Anti-Epileptogenic Potential of Lactuca Serriola Seed Using Pentylenetetrazol-Induced Kindling in Mice and Metabolic Profiling of Its Bioactive Extract

Antioxidants, 2022
This study aimed to assess the potential of Lactuca serriola (Asteraceae) seed n-hexane, chloroform, methanol, and aqueous extracts as anticonvulsant, sedative, anticonvulsant and antiepileptic agents in Swiss albino mice. Different doses of each extract
Muhammad Ihsan Ullah, Rukhsana Anwar, Shahzad Kamran, Bazgha Gul, Sameh S. Elhady, Fadia S. Youssef   +5 more
doaj   +1 more source