Results 21 to 30 of about 47,485 (252)

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Frontiers in Pharmacology, 2022
Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism.
Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima   +18 more
doaj   +1 more source

Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice

Brazilian Journal of Biology, 2023
Ortho-eugenol is a synthetic derivative from eugenol, the major compound of clove essential oil, which has demonstrated antidepressant and antinociceptive effects in pioneering studies.
R. Godoy, A. B. Macedo, K. Y. Gervazio, L. R. Ribeiro, J. L. F. Lima, M. G. S. S. Salvadori   +5 more
doaj   +1 more source

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

Pharmaceuticals, 2021
Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of ...
Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D Clark, Scott Runyon   +10 more
doaj   +1 more source

Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity

Biomedicines, 2023
(1) Background: Adiponectin is an adipocyte-secreted hormone that has antidepressant- and anxiolytic-like effects in preclinical studies. Here, we investigated the antidepressant- and anxiolytic-like effects of sub-chronic treatment with AdipoRon, an ...
Douglas A. Formolo, Thomas H. Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S. Kranz, Suk-Yu Yau   +6 more
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Experimental pharmacological research regarding some new quinazolin-4-ones derivatives

Journal of Mind and Medical Sciences, 2019
A series of new compounds with quinazolin-4-one structure, synthesized by the Pharmaceutical Chemistry Department of the Faculty of Pharmacy of the University of Medicine and Pharmacy “Carol Davila” Bucharest, was studied.
Cornel Chiriță, Emil Ștefănescu, Cristina Elena Zbârcea, Simona Negreș, Mihaela Bratu, Diana Camelia Nuță, Carmen Limban, Ileana Cornelia Chiriță, Cristina Daniela Marineci   +8 more
doaj   +1 more source

Differences in the effects of anxiolytics bromodihydrochlorophenylbenzodiazepine and fabomotizole in patients with anxiety disorders in dependence on their individually-typological features

European Psychiatry, 2022
Introduction Personalized approach in drug therapy is an essential line of modern psychiatry. Experimental and clinical studies of anxiolytics have shown differences in drug effects in dependence on genetically determined reactions to stress and ...
O. Dorofeeva, M. Metlina
doaj   +1 more source

Comparative Study of Piper sylvaticum Roxb. Leaves and Stems for Anxiolytic and Antioxidant Properties Through in vivo, in vitro, and in silico Approaches

Biomedicines, 2020
Piper sylvaticum Roxb. is traditionally used by the indigenous people of tropical and subtropical countries like Bangladesh, India, and China for relieving the common cold or a variety of chronic diseases, such as asthma, chronic coughing, piles ...
Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kama, Md. Obyedul Kalam Azad, Kazi Asfak Ahmed Chowdhury, Mohammad Shah Hafez Kabir, Shaibal Das Gupta, Md. Ashiqur Rahman Chowdhury, Young Seok Lim, Dong Ha Cho   +9 more
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Qualitative phytochemicals and pharmacological properties analysis of methanol extract of Tabernaemontana pauciflora leaves

Journal of Advanced Biotechnology and Experimental Therapeutics, 2021
The methanol extract of the leaves of Tabernaemontana pauciflora (METP) was screened to investigate the semi-qualitative phytochemical, in vivo anti-depressant, anxiolytic and in vitro thrombolytic activities.
Anowar Hossen, Mohammad Arman, Syed Al Jawad Sayem, Mohammad Rifat Alam Maruf, Md. Ahsan Ullah, Mohammad Nazmul Islam, Naureen Banu, Najmul Alam, Shahenur Alam Sakib   +8 more
doaj   +1 more source

Clinical effects of central antagonist of cholecystokinin-1 receptors GB-115 in patients with Generalized Anxiety Disorder

European Psychiatry, 2022
Introduction The pilot clinical study of GB-115, a new peptide antagonist of central cholecystokinin-1 receptors, revealed that drug was clinically effective in patients with generalized anxiety disorder (GAD) at dose 6 mg daily.
O. Dorofeeva, T. Syunyakov, M. Metlina, N. Ivashkina   +3 more
doaj   +1 more source

Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats

Foods
Due to the health benefits of polyphenols and dietary fiber in combating mental disorders, we hypothesized that a polyphenol- and dietary fiber-enriched soup (RJ6601) would improve mental wellness in a rat model of middle-aged women.
Rujikan Chaisanam, Jintanaporn Wattanathorn, Wipawee Thukham-mee, Nawanant Piyavhatkul, Pongsatorn Paholpak   +4 more
doaj   +1 more source