Results 161 to 170 of about 88,094 (292)

Safety, Sedative, and Anxiolytic Evaluation of MECS Hard Capsules Using In Silico and In Vivo Approaches. [PDF]

ACS Omega
Hua OH, Minh Tu P, Thi Thanh Nam N, Van Tat P.   +3 more
europepmc   +1 more source

Phenotypic Variability in Slow‐Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity

Journal of Sleep Research, EarlyView.
ABSTRACT Slow‐wave sleep (SWS; stage N3) is often reported as reduced in depression, yet variability across depressive phenotypes remains poorly characterised. This study aimed to determine whether N3 architecture—proportion, duration, and latency—identifies clinically distinct profiles in major depressive episode (MDE).
Antoine Salmeron, Pierre A. Geoffroy, Lily Vissouze, Jeanne Leseur, Heloise Rach, Michel Lejoyeux, Justine Frija, Marie Pia d’Ortho, Julia Maruani   +8 more
wiley   +1 more source

Sertraline safety in adolescents experiencing a depressive episode during first 3 weeks: added anxiolytic matters more than CYP2C19 polymorphisms. [PDF]

Front Pharmacol
Ivashchenko DV, Sobur VV, Grass SV, Basova AY, Kondratieva RV, Shagovenko EN, Chernetsova YV, Tuchkova SN, Korsakov IN, Markov SI, Mirzaev KB, Shevchenko YS, Sychev D.   +12 more
europepmc   +1 more source

Prescription of Psychotropic Drugs for Chronic Insomnia in Primary Care

Journal of Sleep Research, EarlyView.
ABSTRACT Insomnia is the most prevalent sleep disorder in adults, representing a major public health problem. Healthcare management in a specific area first requires analysing its current practices and issues. We conducted a retrospective observational study of over 100,000 patients from two large primary care databases in the public healthcare ...
Jesús Escribá‐Alepuz, Lidia Herrero‐Huertas, María García‐Gil, Estefanía Estévez‐López, Francisco Javier Puertas, Manuel de Entrambasaguas   +5 more
wiley   +1 more source

Comparative effects of hypnotic agents on sleep architecture and respiratory outcomes in obstructive sleep apnea: A systematic review and network meta‐analysis

Psychiatry and Clinical Neurosciences, EarlyView.
Aim This network meta‐analysis of randomized controlled trials (RCTs) aimed to investigate which hypnotics are associated with the most favorable sleep architecture and respiratory outcomes in adults with obstructive sleep apnea. Methods Primary outcomes included total sleep time (TST) and apnea–hypopnea index (AHI) during TST.
Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Masakazu Hatano, Tatsuhiko Kishi, Tsuyoshi Kitajima, Nakao Iwata   +6 more
wiley   +1 more source

Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota. [PDF]

NPJ Biofilms Microbiomes
Cussotto S, Abdennebi SR, Etting I, Denny CA, Hen R, Colle R, Corruble E, Alvarez JC, David DJ, Mendez-David I.   +9 more
europepmc   +1 more source

Physiological markers of Trauma‐related nightmares among military personnel suffering from PTSD: A multicenter home‐recording study

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Despite being one of the most disabling symptoms of post‐traumatic stress disorder (PTSD)—disrupting sleep continuity, reinforcing hyperarousal, and worsening psychiatric comorbidity—the physiological signature of Trauma‐related nightmares (TRNs) under naturalistic sleep conditions remains poorly characterized.
Dorone Feingold, Michael Quiquempoix, Marion Remadi, Gilles Sipahimalani, Bertrand Lahutte, Damien Léger, Danielle Gomez‐Merino, Mounir Chennaoui, Emeric Saguin   +8 more
wiley   +1 more source

A Novel Functional Ingredient Derived From a Mixture of Mulberry (<i>Morus alba</i> L.) Leaves and Butterfly Pea (<i>Clitoria ternatea</i> L.) Flowers Enhances Rapid Eye Movement Sleep, Cognitive Function, and Anxiolytic Behavior via GABA_A Receptor-Dependent Mechanism in Rats. [PDF]

Oxid Med Cell Longev
Nukitram J, Kanjanavattana A, Rungruang P, Yotyatthai N, Kaewudom P, Promkasikorn P, Kaowsuwan P, Zaima N, Cheaha D, Thukhammee W, Wattanathorn J.   +10 more
europepmc   +1 more source

Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross‐sectional study

Psychiatry and Clinical Neurosciences, EarlyView.
Background Mounting evidence has indicated that multiple major depressive disorder (MDD) episodes are correlated with brain morphometric changes that confer an increased recurrence risk. Functional abnormalities underlying this recurrent vulnerability remain underexplored.
Minxia Jin, Adam W.L. Xia, Wanda M.W. Chau, Nancy M.X.Y. Shi, Penny P. Qin, Bella B.B. Zhang, Rebecca L.D. Kan, Alvin H.P. Tang, Tim T.Z. Lin, Sharie X. Wang, Dicky W.S. Chung, Frank Padberg, Georg S. Kranz   +12 more
wiley   +1 more source

Impact of policy measures targeting benzodiazepines and Benzodiazepine-related drugs in Lithuania: interrupted time series analysis. [PDF]

Eur J Clin Pharmacol
Lasys T, Essink SCM, Santa-Ana-Tellez Y, Siiskonen SJ, Weir DL, Zomerdijk IM, Groenwold RHH, De Bruin ML, Gardarsdottir H.   +8 more
europepmc   +1 more source