Results 221 to 230 of about 88,094 (292)

Divorce conflict and health across the divorce process: A 10‐year observational study of medicine prescriptions, primary care visits and hospitalisations

British Journal of Health Psychology, Volume 31, Issue 2, May 2026.
Abstract Objectives This study examines the association between divorce conflict and medicine prescriptions, primary care visits and hospitalisations, over a 10‐year period around juridical divorce. Design A longitudinal observational study was conducted using a cohort of 1784 Danes who divorced between 2015 and 2017.
Andreas Nielsen Hald, Gert Martin Hald, Peter Fallesen   +2 more
wiley   +1 more source

Neuroactive steroids for the treatment of depression and anxiety: gaps and promises. [PDF]

Eur Arch Psychiatry Clin Neurosci
Rupprecht R, Schüle C, Gudermann T.
europepmc   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice. [PDF]

Transl Psychiatry
Schulte H, Böke H, Lössl P, Worm M, Siveke I, Herlitze S, Spoida K.   +6 more
europepmc   +1 more source

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Safranal-Standardized Saffron Extract Improves Metabolic, Cognitive, and Anxiolytic Outcomes in Aged Mice via Hypothalamic-Amygdalar Peptide Modulation. [PDF]

Nutrients
Navarro JA, Gavito A, Rivas S, Rodríguez-Martín A, Baixeras E, Decara J, Serrano-Castro PJ, Alfonso Y, Sanjuan C, Serrano A, Rodríguez de Fonseca F.   +10 more
europepmc   +1 more source

What Linked Data Can Tell Us About the Increasing Numbers of Children Entering Public Care

Child &Family Social Work, Volume 31, Issue 2, Page 945-960, May 2026.
ABSTRACT The number of children in public care in Wales, UK, rose from the mid‐1990s to 2021. It is unclear if this change was related to increases in risk factors in parents, changes in the impact of risk factors, or changing policies and practices.
Nell Warner, Donald Forrester, Jonathan Scourfield, Rebecca Cannings‐John, Ann John   +4 more
wiley   +1 more source

Efficacy of lurasidone on anxiety symptoms in patients with schizophrenia: A pooled post hoc analysis of five randomized, placebo-controlled trials. [PDF]

PCN Rep
Nemoto T, Okumura M, Maruyama H.
europepmc   +1 more source

Prehospital Risk Stratification Using Unsupervised Machine Learning in STEMI

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Machine learning identified three phenotypes with 30‐day mortality of 3.4%, 22.1%, and 75%. Phenotype‐2 reveals an "occult high‐risk" group: hemodynamically stable yet six‐fold higher mortality. ABSTRACT Background ST‐elevation myocardial infarction (STEMI) exhibits substantial clinical heterogeneity complicating prehospital risk stratification ...
Ana Ramos‐Rodríguez, Raúl López‐Izquierdo, Carlos del Pozo Vegas, María Plaza‐Martín, Cristina Tapia‐Ballesteros, Juan F. Delgado Benito, Ancor Sanz‐García, Francisco Martín‐Rodríguez   +7 more
wiley   +1 more source