Results 21 to 30 of about 49,973 (202)

Structure-Dependent Activity of Natural GABA(A) Receptor Modulators

Molecules, 2018
GABA(A) receptors are ligand-gated ion channels consisting of five subunits from eight subfamilies, each assembled in four hydrophobic transmembrane domains.
Serhat Sezai Çiçek
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Acute stress is detrimental to heart regeneration in zebrafish [PDF]

Open Biology, 2016
Psychological stress is one of the factors associated with human cardiovascular disease. Here, we demonstrate that acute perceived stress impairs the natural capacity of heart regeneration in zebrafish.
Pauline Sallin, Anna Jaźwińska
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Investigation of Potential Antioxidant, Thrombolytic and Neuropharmacological Activities of Homalomena aromatica Leaves Using Experimental and In Silico Approaches

Molecules, 2021
The leaves of Homalomena aromatica are traditionally used in Bangladesh for the treatment of different chronic ailments. The purpose of this study was to explore in vitro antioxidant, thrombolytic activities, and in vivo neuropharmacological effects of ...
Md. Sekendar Ali, Syed Al Jawad Sayem, Habibullah, Yixian Quah, Eon-Bee Lee, Biruk Tesfaye Birhanu, Kyoungho Suk, Seung-Chun Park   +7 more
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Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice

Brazilian Journal of Medical and Biological Research, 2000
The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic benzodiazepine, were examined in mice.
M.A. Rubin, C.A. Albach, D.B. Berlese, H.G. Bonacorso, S.R.T. Bittencourt, C.M.T. Queiroz, A.E. Maixner, C.F. Mello   +7 more
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Effects of ortho-eugenol on anxiety, working memory and oxidative stress in mice

Brazilian Journal of Biology, 2023
Ortho-eugenol is a synthetic derivative from eugenol, the major compound of clove essential oil, which has demonstrated antidepressant and antinociceptive effects in pioneering studies.
R. Godoy, A. B. Macedo, K. Y. Gervazio, L. R. Ribeiro, J. L. F. Lima, M. G. S. S. Salvadori   +5 more
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Latest updates on the serotonergic system in depression and anxiety

Frontiers in Synaptic Neuroscience, 2023
Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being the most disabling subtypes. The two common disorders, depression and anxiety, usually coexist and are pathologically polygenic with complicated
Jianwen Lin, Wenxin Liu, Wenxin Liu, Jing Guan, Jing Guan, Jing Guan, Jianing Cui, Ruolin Shi, Lu Wang, Dong Chen, Yi Liu, Yi Liu   +11 more
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Pharmacological validation of the anxiolytic, muscle relaxant and sedative like activities of Capsicum annuum in animal model

Bangladesh Journal of Pharmacology, 2017
The current study deals with anxiolytic, muscle relaxant and sedative like activities of Capsicum annuum in animal models. The crude extract was found safe in acute behavior and toxicity studies.
Muhammad Jawad, Haroon Khan, Samreen Pervez, Saud S. Bawazeer, Tareq Abu-Izneid, Muhammad Saeed, Mohammad A. Kamal   +6 more
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Dreams, Sleep, and Psychotropic Drugs

Frontiers in Neurology, 2020
Over the past 60 years, the impact of psychotropic drugs on dream recall and content has been scarcely explored. A review of the few existing experimental results on the topic leads us to the following conclusions.
Alain Nicolas, Perrine M. Ruby
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Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Frontiers in Pharmacology, 2022
Disulfiram is an FDA approved drug for the treatment of alcoholism. The drug acts by inhibiting aldehyde dehydrogenase, an enzyme essential to alcohol metabolism.
Akiyoshi Saitoh, Yoshifumi Nagayama, Daisuke Yamada, Kosho Makino, Toshinori Yoshioka, Nanami Yamanaka, Momoka Nakatani, Yoshino Takahashi, Mayuna Yamazaki, Chihiro Shigemoto, Misaki Ohashi, Kotaro Okano, Tomoki Omata, Etsuko Toda, Etsuko Toda, Yoshitake Sano, Hideyo Takahashi, Kouji Matsushima, Yuya Terashima   +18 more
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GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction

Frontiers in Neuroscience, 2019
The Gan-Mai-Da-Zao (GMDZ) decoction is one of the most famous Chinese medicine prescriptions to treat emotional diseases in China. Here we examined the anxiolytic-like effects of the GMDZ decoction in mice.
Hong-Shu Chen, Li-Jia Gu, Li-Jia Gu, Yuan-Xiao Yang, Jian-You Guo, Jian-You Guo, Jian-You Guo   +6 more
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