Results 151 to 160 of about 60,205 (323)

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Neurobiology of Stress, 2019
C. Zorumski, S. Paul, D. Covey, S. Mennerick   +3 more
semanticscholar   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

What Linked Data Can Tell Us About the Increasing Numbers of Children Entering Public Care

Child &Family Social Work, EarlyView.
ABSTRACT The number of children in public care in Wales, UK, rose from the mid‐1990s to 2021. It is unclear if this change was related to increases in risk factors in parents, changes in the impact of risk factors, or changing policies and practices.
Nell Warner, Donald Forrester, Jonathan Scourfield, Rebecca Cannings‐John, Ann John   +4 more
wiley   +1 more source

Association between daily steps, diabetes management and health indicators in people living with type 1 diabetes: A cross‐sectional study from the BETTER registry

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims In people with type 1 diabetes, physical activity provides important health benefits but is mainly limited by fear of hypoglycaemia. Daily step count is a simple indicator of ambulatory activity. This study examined associations between step count and health indicators.
Thélo I. Garré, Capucine G. Guédet, Laure Alexandre‐Heymann, Virginie Messier, Valérie Boudreau, Semah Tagougui, Claude Laforest, Anne‐Sophie Brazeau, Rémi Rabasa‐Lhoret, Jane E. Yardley   +9 more
wiley   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source

Pregabalin contributes to increased recovery time from isoflurane anaesthesia for magnetic resonance imaging in horses

Equine Veterinary Journal, EarlyView.
Abstract Background Pregabalin reduces excitatory neurotransmitter release and is used for anxiolysis in humans, cats, and horses. The effects of pregabalin on equine recovery following isoflurane anaesthesia are unknown. Objectives To determine if pre‐anaesthetic oral pregabalin influences recovery time and/or quality from isoflurane anaesthesia in ...
Abigail Blanton, Kati G. Glass, Jeanette Bayer, Courtney Baetge, Ryota Watanabe, Sarah N. Sampson, Mauricio Lépiz, Kara Moreno, Keila K. Ida   +8 more
wiley   +1 more source

Risk for use of antidepressants, anxiolytics, and hypnotics in partners of glioma patients—A nationwide study covering 19 years of prescriptions

Psycho-Oncology, 2018
Maria R N Jansson, Annika von Heymann-Horan, B. Rasmussen, V. Albieri, K. Frederiksen, N. Suppli, S. Dalton, C. Johansen, P. Bidstrup   +8 more
semanticscholar   +1 more source

A Comparative Investigation of Undergraduate Dental Student Stress in the Management of Deep and Moderate Carious Lesions

International Endodontic Journal, EarlyView.
ABSTRACT Aim The primary objective of this clinical study was to analyse, through physiological and psychological parameters, undergraduate dental student stress during the management of deep compared with moderate carious lesions. Additional objectives aimed to compare student confidence, anxiety and satisfaction during deep and moderate caries ...
V. Chevalier, B. Honari, H. F. Duncan
wiley   +1 more source