Results 81 to 90 of about 2,570 (163)

Transgenic overexpression of the miR‐200b/200a/429 cluster prevents mammary tumor initiation in Neu/Erbb2 transgenic mice

International Journal of Cancer, Volume 156, Issue 5, Page 993-1004, 1 March 2025.
What's new? While miR‐200 s have been suggested to reduce breast cancer growth and metastasis, whether these microRNAs can prevent mammary tumor development in the first place is unknown. Using a transgenic model of HER2+ breast cancer, this study found that elevated expression of miR‐200 family members in mouse mammary epithelial cells can completely ...
Katrina L. Watson, Roger A. Moorehead
wiley   +1 more source

Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. [PDF]

, 2016
Viruses are intracellular pathogens that hijack host cell machinery and resources to replicate. Rather than being constant, host physiology is rhythmic, undergoing circadian (∼24 h) oscillations in many virus-relevant pathways, but whether daily rhythms ...
Edgar, Rachel S, Efstathiou, Stacey, Nagy, Andras D, Nicoll, Michael P, O'Neill, John S, Reddy, Akhilesh B, Stangherlin, Alessandra   +6 more
core   +2 more sources

A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver disease

Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Performed comprehensive genomics across liver biopsies of 396 MASLD patients and identified patients with increased, decreased and unchanged FGF21 expression. Used genomic data from FGF21 transgenic, knock‐out and animal MASLD models treated with synthetic FGF21 analogues to identify FGF21‐mode‐of‐action and metabolic networks in human MASLD. Given the
Shifang Tang, Jürgen Borlak
wiley   +1 more source

Recent developments on the role of epigenetics in obesity and metabolic disease [PDF]

, 2015
The increased prevalence of obesity and related comorbidities is a major public health problem. While genetic factors undoubtedly play a role in determining individual susceptibility to weight gain and obesity, the identified genetic variants only ...
Beverly S. Muhlhausler, Janna L. Morrison, Peter L. Molloy, Ross L. Tellam, Susan J. van Dijk   +4 more
core   +1 more source

Fashion and sustainability: Evidence from the consumption of second‐hand clothes

Corporate Social Responsibility and Environmental Management, Volume 32, Issue 1, Page 947-962, January 2025.
Abstract Companies are becoming increasingly involved with sustainability as various stakeholders require them to orient their activities in line with sustainability and its principles. In some industries, such as the food industry and the fashion industry, these requests are particularly relevant because they are considered to be keenly related to ...
Fabiana Sepe, Muto Valerio, Prisco Anna, Tani Mario   +3 more
wiley   +1 more source

Bacterial volatile organic compounds supplemented with light‐emitting diode lighting enhance antioxidant capacity and delay senescence in broccoli

Food Frontiers, Volume 6, Issue 1, Page 448-464, January 2025.
Bacterial volatile organic compounds (BVOCs) are biological volatiles that can have a positive effect on the postharvest preservation of fruits and vegetables. In the present study, fumigation of broccoli with BVOCs released by Lysinibacillus fusiformis supplemented with LED white light irradiation reduced the accumulation of reactive oxygen species ...
Taishan Huang, Junyan Shi, Xiaozhen Yue, Shuzhi Yuan, Xiangbin Xu, Jinhua Zuo, Qing Wang   +6 more
wiley   +1 more source

Increased Vascular Adhesion Protein 1 (VAP-1) Levels Are Associated with Alternative M2 Macrophage Activation and Poor Prognosis for Human Gliomas

Diagnostics, 2020
Glioma is characterized by a high heterogeneity in the brain tumor. Abundant tumor-associated macrophages (TAMs) exist as neoplastic tissues, implicating tumor plasticity and thus leading to therapeutic challenges.
Shu-Jyuan Chang, Hung-Pin Tu, Yen-Chang Clark Lai, Chi-Wen Luo, Takahide Nejo, Shota Tanaka, Chee-Yin Chai, Aij-Lie Kwan   +7 more
doaj   +1 more source

Integration of multi‐omics layers empowers precision diagnosis through unveiling pathogenic mechanisms on maple syrup urine disease

Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.
Abstract Maple syrup urine disease (MSUD) is a rare inherited metabolic disorder characterized by deficient activity of the branched‐chain alpha‐ketoacid dehydrogenase (BCKDH) complex, required to metabolize the amino acids leucine, isoleucine, and valine.
Juan Ramón Tejedor, Alejandro Soriano‐Sexto, Leonardo Beccari, Natalia Castejón‐Fernández, Patricia Correcher, Lidia Sainz‐Ledo, Juan José Alba‐Linares, Rocío G. Urdinguio, Magdalena Ugarte, Agustín F. Fernández, Pilar Rodríguez‐Pombo, Mario F. Fraga, Belén Pérez   +12 more
wiley   +1 more source

A Deep Differential Analysis in Four Subtypes of Breast Cancer Based on Regulations of miRNA‐mRNA

IET Systems Biology, Volume 19, Issue 1, January/December 2025.
The main task of this study is to predict the missing regulations of miRNA‐mRNA based on background network in four subtypes of breast cancer. Moreover, the predicted regulations of miRNA‐mRNA are further compared to identify the differences among four subtypes of breast cancer.
Tao Huang, Ling Guo, Weiyuan Ma, Yue Pan
wiley   +1 more source

Human Copper-Dependent Amine Oxidases [PDF]

, 2018
Copper amine oxidases (CAOs) are a class of enzymes that contain Cu2+ and a tyrosine-derived quinone cofactor, catalyze the conversion of a primary amine functional group to an aldehyde, and generate hydrogen peroxide and ammonia as byproducts.
Finney, Joel, Lantz, Mason, Moon, Hee-Jung, Mure, Minae, Ronnebaum, Trey   +4 more
core   +1 more source