Results 61 to 70 of about 2,570 (163)

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs [PDF]

, 2014
© 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.BACKGROUND: Cardiovascular ...
Ahmetaj-Shala, Blerina, Al'Yamani, Malak, Armstrong, Paul C. J., Kirkby, Nicholas S., Knowles, Rebecca, Leiper, James, Mackenzie, Louise, Mazi, Sarah, Mitchell, Jane A., Nüsing, Rolf M., Tomlinson, James A. P., Tucker, Arthur T., Wang, Zhen, Warner, Timothy D.   +13 more
core   +4 more sources

Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer

iMetaMed, Volume 1, Issue 2, December 2025.
We performed network perturbation analysis on transcriptomic data from endometrial cancer patients across multiple cohorts and identified three molecular subtypes with distinct clinical outcomes. The most aggressive subtype, C1, exhibits comprehensive molecular and immunological alterations, including dysregulated hormone signaling, immune exclusion ...
Jie Liu, Yuxuan Song, Yiqin Wang, Shaolei Li, YuanYuan Ma, Meng Zhang, Keran Sun, Yibo He, Hengrui Liu, Hao Chi, Jingyuan Ning   +10 more
wiley   +1 more source

State space mixed models for longitudinal obsservations with binary and binomial responses [PDF]

, 2006
We propose a new class of state space models for longitudinal discrete response data where the observation equation is specified in an additive form involving both deterministic and random linear predictors.
Czado, Claudia, Song, Peter X.-K.
core   +2 more sources

Identification of Glutathione Synthetase as a Therapeutic Target for Cervical Cancer via Combining Bioinformatics and Experimental Validation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 24, December 2025.
ABSTRACT Cervical cancer remains a leading cause of cancer‐related mortality among women worldwide, posing a severe threat to female health. Previous research indicates that cuproptosis is a copper‐dependent form of regulated cell death, holding potential as a therapeutic avenue. This study aimed to identify and validate Cuproptosis‐Related Genes (CRGs)
Meini Pan, Tingzhuang Yi, Peng Lei, Jiangmi Mo, Jinyan Lan, Yulu Ye, Hongqian Wang, Cheng Yuan, Zhaohe Huang   +8 more
wiley   +1 more source

EctoShed: a novel gene delivery platform for functional analysis of adipocyte-shed proteoforms

BMC Research Notes
Objective The proteolytic cleavage of membrane-bound proteins, ectodomain shedding, functionally expands the reservoir of proteins/peptides available for endocrine crosstalk, and metabolic regulation.
Ana Rita Tavanez, Nadia Meincke Egedal, Natasa Stanic, Hande Topel, Jan-Wilhelm Kornfeld   +4 more
doaj   +1 more source

Suppression of cancer stemness p21-regulating mRNA and microRNA signatures in recurrent ovarian cancer patient samples [PDF]

, 2012
Background Malignant ovarian disease is characterised by high rates of mortality due to high rates of recurrent chemoresistant disease. Anecdotal evidence indicates this may be due to chemoresistant properties of cancer stem cells (CSCs).
Michael F Gallagher, Cynthia CBB Heffron, Alexandros Laios, Sharon A O'Toole, Brendan Ffrench, Paul C Smyth, Richard J Flavin, Salah A Elbaruni, Cathy D Spillane, Cara M Martin, Orla M Sheils, John J O'Leary   +11 more
core   +1 more source

p‐Cymene Targets Multiple Oncogenic Pathways in Hepatocellular Carcinoma: Insights From Network Pharmacology and In Vitro Studies

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
p‐Cymene exhibited a strong affinity for key hepatocellular carcinoma (HCC) targets and induced dose‐dependent cytotoxicity in HepG2 cells while enhancing antioxidant defense mechanisms. The treatment significantly modulated apoptotic and angiogenic markers, notably increasing Caspase‐3 and p53, and suppressing BCL2 and VEGF expression.
Nadia Anwar, Muhammad Nasir Hayat Malik, Muhammad Atif, Abdullah R. Alanzi, Hattan A. Alharbi, Waqas Younis, Munawar Abbas, Gideon F. B. Solre   +7 more
wiley   +1 more source

Activity Regulation by Heteromerization of Arabidopsis Allene Oxide Cyclase Family Members

Plants, 2016
Jasmonates (JAs) are lipid-derived signals in plant stress responses and development. A crucial step in JA biosynthesis is catalyzed by allene oxide cyclase (AOC).
Markus Otto, Christin Naumann, Wolfgang Brandt, Claus Wasternack, Bettina Hause   +4 more
doaj   +1 more source

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep

BMC Genomics, 2023
Background The detection of selective traits in different populations can not only reveal current mechanisms of artificial selection for breeding, but also provide new insights into phenotypic variation in new varieties and the search for genes ...
Huibin Shi, Taotao Li, Manchun Su, Huihui Wang, Qiao Li, Xia Lang, Youji Ma   +6 more
doaj   +1 more source

A meta-analysis of public microarray data identifies gene regulatory pathways deregulated in peripheral blood mononuclear cells from individuals with Systemic Lupus Erythematosus compared to those without [PDF]

, 2016
BACKGROUND: Systemic Lupus Erythematosus (SLE) is a complex, multi-systemic, autoimmune disease for which the underlying aetiological mechanisms are poorly understood.
Entfellner, Jean-Baka Domelevo, Kroger, Wendy, Mapiye, Darlington, Tiffin, Nicki   +3 more
core   +3 more sources