Circular RNA and mRNA profiling reveal competing endogenous RNA networks during avian leukosis virus, subgroup J-induced tumorigenesis in chickens. [PDF]
PLoS ONE, 2018 Avian leukosis virus subgroup J (ALV-J) can induce myeloid tumors and hemangiomas in chickens and causes severe economic losses with commercial layer chickens and meat-type chickens.
Lingling Qiu +4 more
doaj +1 more source
Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]
, 2017 The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul +5 more
core +2 more sources
Archiv der Pharmazie, 2022 AbstractAmine oxidase copper containing 3 (AOC3), also known as plasma amine oxidase, semicarbazide‐sensitive amine oxidase, or vascular adhesion protein‐1, catalyzes the oxidative deamination of primary amines to aldehydes using copper and a quinone as cofactors.
Florian Galster +3 more
openaire +2 more sources
Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice [PDF]
, 2018 Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice.
Carpéné, Christian +3 more
core +2 more sources
LINC01936 inhibits the proliferation and metastasis of lung squamous cell carcinoma probably by EMT signaling and immune infiltration [PDF]
PeerJ, 2023 Purpose To discover the biological function and potential mechanism of LINC01936 in the development of lung squamous cell carcinoma (LUSC). Methods Transcriptome data of LUSC from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases
Qinqin Tian +9 more
doaj +2 more sources
Cells, 2023 Circadian rhythm governs many aspects of liver physiology and its disruption exacerbates chronic disease. CLOCKΔ19 mice disrupted circadian rhythm and spontaneously developed obesity and metabolic syndrome, a phenotype that parallels the progression of ...
Elliot Jokl +14 more
doaj +1 more source
Smooth Muscle-Generated Methylglyoxal Impairs Endothelial Cell-Mediated Vasodilatation of Cerebral Microvessels in Type 1 Diabetic Rats [PDF]
, 2016 Background and Purpose Endothelial cell-mediated vasodilatation of cerebral arterioles is impaired in individuals with Type 1 diabetes (T1D). This defect compromises haemodynamics and can lead to hypoxia, microbleeds, inflammation and exaggerated ...
Alomar, Fadhel +7 more
core +1 more source
Sci, 2021 Toll-like receptor 5 ligand, flagellin, and vascular adhesion protein 1 (VAP-1) are involved in non-alcoholic fatty liver disease. This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation.
Raine Toivonen +9 more
doaj +1 more source
Architecture and dynamics of the jasmonic acid gene regulatory network [PDF]
, 2017 Jasmonic acid (JA) is a critical hormonal regulator of plant growth and defense. To advance our understanding of the architecture and dynamic regulation of the JA gene regulatory network, we performed a high-resolution RNA-seq time series of methyl JA ...
Caarls, Lotte +16 more
core +2 more sources
Human Copper-Containing Amine Oxidases in Drug Design and Development
Molecules, 2020 Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3 ...
Serhii Vakal +3 more
doaj +1 more source