Integrative machine learning model for subtype identification and prognostic prediction in lung squamous cell carcinoma [PDF]
Discover OncologyBackground Lung squamous cell carcinoma (LUSC) is a leading cause of cancer-related mortality, and tumor heterogeneity could result in diverse prognostic subtypes.
Guangliang Duan +6 more
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Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3 [PDF]
Open Biology, 2020 Zinc-α2-glycoprotein (ZAG) is a major plasma protein whose levels increase in chronic energy-demanding diseases and thus serves as an important clinical biomarker in the diagnosis and prognosis of the development of cachexia.
Matthias Romauch
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Association of
Obes Facts<p>Introduction: Soluble vascular adhesion protein-1 (sVAP-1), which is identical to semicarbazide-sensitive amine oxidase (SSAO), contributes to oxidative stress and vascular dysfunction. The AOC3 gene that encodes VAP-1 is mainly expressed in vascular endothelial and smooth muscle cells, but AOC3 expression in adipose tissue and vascular ...
Horikawa O +9 more
europepmc +4 more sources
Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis. [PDF]
In VivoInflammatory bowel diseases and colorectal cancer are a major cause of morbidity and mortality. Amine oxidase, copper-containing 3 (AOC3) is a critical enzyme in the physiological trafficking of leukocytes and the regulation of inflammation.
Özcan Ö, Akyol Ö, Akyol A.
europepmc +4 more sources
Endothelial cell-derived SSAO can increase MLC20 phosphorylation in VSMCs
Open Life Sciences, 2021 Vascular hyporesponsiveness in the shock decompensation period is an important factor leading to death. Myosin light chain 20 (MLC20) is the main effector protein that regulates vascular reactivity.
Zhang Yuxing +5 more
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Molecular Plant-Microbe Interactions, 2022 Rhizosphere-competent microbes often interact with plant roots and exhibit beneficial effects on plant performance. Numerous bacterial and fungal isolates are able to prime host plants for fast adaptive responses against pathogen attacks. Combined action
Fatema Binte Hafiz +9 more
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Biomolecules, 2022 Vascular smooth muscle cells (VSMCs) are the main stromal cells in the medial layer of the vascular wall. These cells produce the extracellular matrix (ECM) and are involved in many pathological changes in the vascular wall. Semicarbazide-sensitive amine
Vesna Manasieva +5 more
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ROBIN: a randomised, double-masked, placebo-controlled Phase IIa study of the AOC3 inhibitor BI 1467335 in diabetic retinopathy. [PDF]
Eye (Lond)Abstract Objective To evaluate the safety and efficacy of BI 1467335 in patients with non-proliferative diabetic retinopathy (NPDR). Methods ROBIN is a Phase IIa, double-masked, randomised, placebo-controlled study (NCT03238963).
Dong Nguyen Q +6 more
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A novel immune cell signature for predicting osteosarcoma prognosis and guiding therapy
Frontiers in Immunology, 2022 Dysregulation of immune cell infiltration in the tumor microenvironment contributes to the progression of osteosarcoma (OS). In the present study, we explored genes related to immune cell infiltration and constructed a risk model to predict the prognosis
Runsang Pan +13 more
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Multiple roles for UV RESISTANCE LOCUS8 in regulating gene expression and metabolite accumulation in arabidopsis under solar ultraviolet radiation [PDF]
, 2013 Photomorphogenic responses triggered by low fluence rates of ultraviolet B radiation (UV-B; 280–315 nm) are mediated by the UV-B photoreceptor UV RESISTANCE LOCUS8 (UVR8).
Aphalo, P.J. +9 more
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